The links below are to publications on PubMed referring to PPMI. This list is gathered weekly from PubMed automatically and was last updated on December 17, 2025.

Publication/References
Genetics of Parkinson's disease: An introspection of its journey towards precision medicine.
Description: Bandres-Ciga, Sara, et al. Genetics of Parkinson's disease: An introspection of its journey towards precision medicine. ''Neurobiol Dis''. 2020 Apr; '''137''': 104782
Brainstem atrophy in Gulf War Illness.
Description: Zhang, Yu, et al. Brainstem atrophy in Gulf War Illness. ''Neurotoxicology''. 2020 May; '''78''': 71-79
Choroid plexus volume is associated with levels of CSF proteins: relevance for Alzheimer's and Parkinson's disease.
Description: Tadayon, Ehsan, et al. Choroid plexus volume is associated with levels of CSF proteins: relevance for Alzheimer's and Parkinson's disease. ''Neurobiol Aging''. 2020 May; '''89''': 108-117
A Survey of Rare Epigenetic Variation in 23,116 Human Genomes Identifies Disease-Relevant Epivariations and CGG Expansions.
Description: Garg, Paras, et al. A Survey of Rare Epigenetic Variation in 23,116 Human Genomes Identifies Disease-Relevant Epivariations and CGG Expansions. ''Am J Hum Genet''. 2020 Oct 1; '''107''' (4):654-669
Deep brain stimulation: Imaging on a group level.
Description: Treu, Svenja, et al. Deep brain stimulation: Imaging on a group level. ''Neuroimage''. 2020 Oct 1; '''219''': 117018
Longitudinal evolution of non-motor symptoms according to age at onset in early Parkinson's disease.
Description: Kim, Ryul, et al. Longitudinal evolution of non-motor symptoms according to age at onset in early Parkinson's disease. ''J Neurol Sci''. 2020 Nov 15; '''418''': 117157
Extrastriatal SPECT-DAT uptake correlates with clinical and biological features of de novo Parkinson's disease.
Description: Sampedro, Frederic, et al. Extrastriatal SPECT-DAT uptake correlates with clinical and biological features of de novo Parkinson's disease. ''Neurobiol Aging''. 2021 Jan; '''97''': 120-128
Normative vs. patient-specific brain connectivity in deep brain stimulation.
Description: Wang, Qiang, et al. Normative vs. patient-specific brain connectivity in deep brain stimulation. ''Neuroimage''. 2021 Jan 1; '''224''': 117307
Assessment of LIN28A variants in Parkinson's disease in large European cohorts.
Description: Diez-Fairen, Monica, et al. Assessment of LIN28A variants in Parkinson's disease in large European cohorts. ''Neurobiol Aging''. 2021 Apr; '''100''': 118.e1-118.e3
Investigating ELOVL7 coding variants in multiple system atrophy.
Description: Wernick, Anna I, et al. Investigating ELOVL7 coding variants in multiple system atrophy. ''Neurosci Lett''. 2021 Apr 1; '''749''': 135723
Distinct neural circuits are associated with subclinical neuropsychiatric symptoms in Parkinson's disease.
Description: Tinaz, Sule, et al. Distinct neural circuits are associated with subclinical neuropsychiatric symptoms in Parkinson's disease. ''J Neurol Sci''. 2021 Apr 15; '''423''': 117365
Retrospective motion artifact correction of structural MRI images using deep learning improves the quality of cortical surface reconstructions.
Description: Duffy, Ben A, et al. Retrospective motion artifact correction of structural MRI images using deep learning improves the quality of cortical surface reconstructions. ''Neuroimage''. 2021 Apr 15; '''230''': 117756
Pervasive cis effects of variation in copy number of large tandem repeats on local DNA methylation and gene expression.
Description: Garg, Paras, et al. Pervasive cis effects of variation in copy number of large tandem repeats on local DNA methylation and gene expression. ''Am J Hum Genet''. 2021 May 6; '''108''' (5):809-824
Folded concave penalized learning of high-dimensional MRI data in Parkinson's disease.
Description: Li, Changcheng, et al. Folded concave penalized learning of high-dimensional MRI data in Parkinson's disease. ''J Neurosci Methods''. 2021 Jun 1; '''357''': 109157
An individualized prediction of time to cognitive impairment in Parkinson's disease: A combined multi-predictor study.
Description: Tang, Chunyan, et al. An individualized prediction of time to cognitive impairment in Parkinson's disease: A combined multi-predictor study. ''Neurosci Lett''. 2021 Sep 25; '''762''': 136149
White matter changes in drug-naive Parkinson's disease patients with impulse control & probable REM sleep behavior disorders.
Description: Dolatshahi, Mahsa, et al. White matter changes in drug-naive Parkinson's disease patients with impulse control & probable REM sleep behavior disorders. ''J Neurol Sci''. 2021 Nov 15; '''430''': 120032
Alterations in white matter fiber in Parkinson disease across different cognitive stages.
Description: Sang, Tian, et al. Alterations in white matter fiber in Parkinson disease across different cognitive stages. ''Neurosci Lett''. 2022 Jan 19; '''769''': 136424
White matter hyperintensities are associated with grey matter atrophy and cognitive decline in Alzheimer's disease and frontotemporal dementia.
Description: Dadar, Mahsa, et al. White matter hyperintensities are associated with grey matter atrophy and cognitive decline in Alzheimer's disease and frontotemporal dementia. ''Neurobiol Aging''. 2022 Mar; '''111''': 54-63
Regional changes of brain structure during progression of idiopathic Parkinson's disease - A longitudinal study using deformation based morphometry.
Description: Pieperhoff, Peter, et al. Regional changes of brain structure during progression of idiopathic Parkinson's disease - A longitudinal study using deformation based morphometry. ''Cortex''. 2022 Jun; '''151''': 188-210
A phenome-wide association study identifies effects of copy-number variation of VNTRs and multicopy genes on multiple human traits.
Description: Garg, Paras, et al. A phenome-wide association study identifies effects of copy-number variation of VNTRs and multicopy genes on multiple human traits. ''Am J Hum Genet''. 2022 Jun 2; '''109''' (6):1065-1076
A model-based approach to assess reproducibility for large-scale high-throughput MRI-based studies.
Description: Jiao, Zeyu, et al. A model-based approach to assess reproducibility for large-scale high-throughput MRI-based studies. ''Neuroimage''. 2022 Jul 15; '''255''': 119166
DARQ: Deep learning of quality control for stereotaxic registration of human brain MRI to the T1w MNI-ICBM 152 template.
Description: Fonov, Vladimir S, et al. DARQ: Deep learning of quality control for stereotaxic registration of human brain MRI to the T1w MNI-ICBM 152 template. ''Neuroimage''. 2022 Aug 15; '''257''': 119266
Olfaction and apathy in early idiopathic Parkinson's disease.
Description: Martinez-Nunez, Alfonso E, et al. Olfaction and apathy in early idiopathic Parkinson's disease. ''J Neurol Sci''. 2022 Aug 15; '''439''': 120314
Brain functional network abnormalities in parkinson's disease with mild cognitive impairment.
Description: Suo, Xueling, et al. Brain functional network abnormalities in parkinson's disease with mild cognitive impairment. ''Cereb Cortex''. 2022 Oct 20; '''32''' (21):4857-4868
Motor symptoms in Parkinson's disease are related to the interplay between cortical curvature and thickness.
Description: Almgren, Hannes, et al. Motor symptoms in Parkinson's disease are related to the interplay between cortical curvature and thickness. ''Neuroimage Clin''. 2022 Dec 21; '''37''': 103300
Baseline cerebral structural morphology predict freezing of gait in early drug-naive Parkinson's disease.
Description: Li, Yuting, et al. Baseline cerebral structural morphology predict freezing of gait in early drug-naive Parkinson's disease. ''NPJ Parkinsons Dis''. 2022 Dec 29; '''8''' (1):176
Altered dynamic functional network connectivity in drug-naive Parkinson's disease patients with excessive daytime sleepiness.
Description: Tan, Zhiyi, et al. Altered dynamic functional network connectivity in drug-naive Parkinson's disease patients with excessive daytime sleepiness. ''Front Aging Neurosci''. 2023; '''15''': 1282962
Freezing of gait is a risk factor for cognitive decline in Parkinson's disease.
Description: Qu, Yi, et al. Freezing of gait is a risk factor for cognitive decline in Parkinson's disease. ''J Neurol''. 2023 Jan; '''270''' (1):466-476
Genome- and Exome-Wide Association Studies Revealed Candidate Genes Associated with DaTscan Imaging Features.
Description: Yaghoobi, Arash, et al. Genome- and Exome-Wide Association Studies Revealed Candidate Genes Associated with DaTscan Imaging Features. ''Parkinsons Dis''. 2023; '''2023''': 2893662
Microglia ferroptosis is regulated by SEC24B and contributes to neurodegeneration.
Description: Ryan, Sean K, et al. Microglia ferroptosis is regulated by SEC24B and contributes to neurodegeneration. ''Nat Neurosci''. 2023 Jan; '''26''' (1):12-26
Network connectivity and local transcriptomic vulnerability underpin cortical atrophy progression in Parkinson's disease.
Description: Vo, Andrew, et al. Network connectivity and local transcriptomic vulnerability underpin cortical atrophy progression in Parkinson's disease. ''Neuroimage Clin''. 2023; '''40''': 103523
Neurodegenerative disease of the brain: a survey of interdisciplinary approaches.
Description: Davenport, Franca, et al. Neurodegenerative disease of the brain: a survey of interdisciplinary approaches. ''J R Soc Interface''. 2023 Jan; '''20''' (198):20220406
Nomogram for Early Prediction of Parkinson's Disease Based on microRNA Profiles and Clinical Variables.
Description: Hou, Xiangqing, et al. Nomogram for Early Prediction of Parkinson's Disease Based on microRNA Profiles and Clinical Variables. ''J Parkinsons Dis''. 2023; '''13''' (4):473-484
Nomogram to Predict the Probability of Functional Dependence in Early Parkinson's Disease.
Description: Valent, Dora, et al. Nomogram to Predict the Probability of Functional Dependence in Early Parkinson's Disease. ''J Parkinsons Dis''. 2023; '''13''' (1):49-55
Parkinson's Progression Markers Initiative: A Milestone-Based Strategy to Monitor Parkinson's Disease Progression.
Description: Brumm, Michael C, et al. Parkinson's Progression Markers Initiative: A Milestone-Based Strategy to Monitor Parkinson's Disease Progression. ''J Parkinsons Dis''. 2023; '''13''' (6):899-916
Serum Uric Acid as a Putative Biomarker in Prodromal Parkinson's Disease: Longitudinal Data from the PPMI Study.
Description: Koros, Christos, et al. Serum Uric Acid as a Putative Biomarker in Prodromal Parkinson's Disease: Longitudinal Data from the PPMI Study. ''J Parkinsons Dis''. 2023; '''13''' (5):811-818
Sex Differences in Brain Structure in de novo Parkinson's Disease: A Cross-Sectional and Longitudinal Neuroimaging Study.
Description: Li, Hui, et al. Sex Differences in Brain Structure in de novo Parkinson's Disease: A Cross-Sectional and Longitudinal Neuroimaging Study. ''J Parkinsons Dis''. 2023; '''13''' (5):785-795
The longitudinal progression of autonomic dysfunction in Parkinson's disease: A 7-year study.
Description: Stewart, Charlotte B, et al. The longitudinal progression of autonomic dysfunction in Parkinson's disease: A 7-year study. ''Front Neurol''. 2023; '''14''': 1155669
Topological analysis of functional connectivity in Parkinson's disease.
Description: Zhang, Weiwei, et al. Topological analysis of functional connectivity in Parkinson's disease. ''Front Neurosci''. 2023; '''17''': 1236128
Transcriptome Analysis Reveals a Two-Gene Signature Links to Motor Progression and Alterations of Immune Cells in Parkinson's Disease.
Description: Li, Weimin, et al. Transcriptome Analysis Reveals a Two-Gene Signature Links to Motor Progression and Alterations of Immune Cells in Parkinson's Disease. ''J Parkinsons Dis''. 2023; '''13''' (1):25-38
BundleWarp, streamline-based nonlinear registration of white matter tracts.
Description: Chandio, Bramsh Qamar, et al. BundleWarp, streamline-based nonlinear registration of white matter tracts. ''bioRxiv''. 2023 Jan 5;
Peripheral inflammatory immune response differs among sporadic and familial Parkinson's disease.
Description: Munoz-Delgado, Laura, et al. Peripheral inflammatory immune response differs among sporadic and familial Parkinson's disease. ''NPJ Parkinsons Dis''. 2023 Jan 31; '''9''' (1):12
DBSegment: Fast and robust segmentation of deep brain structures considering domain generalization.
Description: Baniasadi, Mehri, et al. DBSegment: Fast and robust segmentation of deep brain structures considering domain generalization. ''Hum Brain Mapp''. 2023 Feb 1; '''44''' (2):762-778
Genome-wide evaluation of the effect of short tandem repeat variation on local DNA methylation.
Description: Martin-Trujillo, Alejandro, et al. Genome-wide evaluation of the effect of short tandem repeat variation on local DNA methylation. ''Genome Res''. 2023 Feb; '''33''' (2):184-196
A proteogenomic view of Parkinson's disease causality and heterogeneity.
Description: Kaiser, Sergio, et al. A proteogenomic view of Parkinson's disease causality and heterogeneity. ''NPJ Parkinsons Dis''. 2023 Feb 11; '''9''' (1):24
LRRK2 and GBA1 variant carriers have higher urinary bis(monacylglycerol) phosphate concentrations in PPMI cohorts.
Description: Merchant, Kalpana M, et al. LRRK2 and GBA1 variant carriers have higher urinary bis(monacylglycerol) phosphate concentrations in PPMI cohorts. ''NPJ Parkinsons Dis''. 2023 Feb 28; '''9''' (1):30
Association of rare variants in ARSA with Parkinson's disease.
Description: Senkevich, Konstantin, et al. Association of rare variants in ARSA with Parkinson's disease. ''medRxiv''. 2023 Mar 13;
Lifespan Neurodegeneration Of The Human Brain In Multiple Sclerosis.
Description: Coupe, Pierrick, et al. Lifespan Neurodegeneration Of The Human Brain In Multiple Sclerosis. ''bioRxiv''. 2023 Mar 14;
Elevated urine BMP phospholipids in LRRK2 and VPS35 mutation carriers with and without Parkinson's disease.
Description: Gomes, Sara, et al. Elevated urine BMP phospholipids in LRRK2 and VPS35 mutation carriers with and without Parkinson's disease. ''NPJ Parkinsons Dis''. 2023 Apr 4; '''9''' (1):52
The systematic comparison between Gaussian mirror and Model-X knockoff models.
Description: Chen, Shuai, et al. The systematic comparison between Gaussian mirror and Model-X knockoff models. ''Sci Rep''. 2023 Apr 4; '''13''' (1):5478
Exploring the genetic and genomic connection underlying neurodegeneration with brain iron accumulation and the risk for Parkinson's disease.
Description: Alvarez Jerez, Pilar, et al. Exploring the genetic and genomic connection underlying neurodegeneration with brain iron accumulation and the risk for Parkinson's disease. ''NPJ Parkinsons Dis''. 2023 Apr 6; '''9''' (1):54
Genome-wide association study stratified by MAPT haplotypes identifies potential novel loci in Parkinson's disease.
Description: Senkevich, Konstantin, et al. Genome-wide association study stratified by MAPT haplotypes identifies potential novel loci in Parkinson's disease. ''medRxiv''. 2023 Apr 15;
Explainable classification of Parkinson's disease using deep learning trained on a large multi-center database of T1-weighted MRI datasets.
Description: Camacho, Milton, et al. Explainable classification of Parkinson's disease using deep learning trained on a large multi-center database of T1-weighted MRI datasets. ''Neuroimage Clin''. 2023 Apr 17; '''38''': 103405
Updated Percentiles for the University of Pennsylvania Smell Identification Test in Adults 50 Years of Age and Older.
Description: Brumm, Michael C, et al. Updated Percentiles for the University of Pennsylvania Smell Identification Test in Adults 50 Years of Age and Older. ''Neurology''. 2023 Apr 18; '''100''' (16):e1691-e1701
Estimating uncertainty in read-out patterns: Application to controls-based denoising and voxel-based morphometry patterns in neurodegenerative and neuropsychiatric diseases.
Description: Blum, Dominik, et al. Estimating uncertainty in read-out patterns: Application to controls-based denoising and voxel-based morphometry patterns in neurodegenerative and neuropsychiatric diseases. ''Hum Brain Mapp''. 2023 May; '''44''' (7):2802-2814
Functional screening of lysosomal storage disorder genes identifies modifiers of alpha-synuclein neurotoxicity.
Description: Yu, Meigen, et al. Functional screening of lysosomal storage disorder genes identifies modifiers of alpha-synuclein neurotoxicity. ''PLoS Genet''. 2023 May; '''19''' (5):e1010760
Long-term cognitive decline prediction based on multi-modal data using Multimodal3DSiameseNet: transfer learning from Alzheimer's disease to Parkinson's disease.
Description: Ostertag, Cecilia, et al. Long-term cognitive decline prediction based on multi-modal data using Multimodal3DSiameseNet: transfer learning from Alzheimer's disease to Parkinson's disease. ''Int J Comput Assist Radiol Surg''. 2023 May; '''18''' (5):809-818
Association between the LRP1B and APOE loci and the development of Parkinson's disease dementia.
Description: Real, Raquel, et al. Association between the LRP1B and APOE loci and the development of Parkinson's disease dementia. ''Brain''. 2023 May 2; '''146''' (5):1873-1887
GALC variants affect galactosylceramidase enzymatic activity and risk of Parkinson's disease.
Description: Senkevich, Konstantin, et al. GALC variants affect galactosylceramidase enzymatic activity and risk of Parkinson's disease. ''Brain''. 2023 May 2; '''146''' (5):1859-1872
Moderating effects of uric acid and sex on cognition and psychiatric symptoms in asymmetric Parkinson's disease.
Description: Constantin, Ioana Medeleine, et al. Moderating effects of uric acid and sex on cognition and psychiatric symptoms in asymmetric Parkinson's disease. ''Biol Sex Differ''. 2023 May 4; '''14''' (1):26
Radiomic tractometry: a rich and tract-specific class of imaging biomarkers for neuroscience and medical applications.
Description: Neher, Peter, et al. Radiomic tractometry: a rich and tract-specific class of imaging biomarkers for neuroscience and medical applications. ''Res Sq''. 2023 May 23;
Genetic meta-analysis of levodopa induced dyskinesia in Parkinson's disease.
Description: Martinez-Carrasco, Alejandro, et al. Genetic meta-analysis of levodopa induced dyskinesia in Parkinson's disease. ''medRxiv''. 2023 May 30;
Deep fiber clustering: Anatomically informed fiber clustering with self-supervised deep learning for fast and effective tractography parcellation.
Description: Chen, Yuqian, et al. Deep fiber clustering: Anatomically informed fiber clustering with self-supervised deep learning for fast and effective tractography parcellation. ''Neuroimage''. 2023 Jun; '''273''': 120086
Dissociable effects of dopaminergic medications on depression symptom dimensions in Parkinson's disease.
Description: Costello, Harry, et al. Dissociable effects of dopaminergic medications on depression symptom dimensions in Parkinson's disease. ''medRxiv''. 2023 Jun 30;
Age and sex differentially shape brain networks in Parkinson's disease.
Description: Chen, Zhichun, et al. Age and sex differentially shape brain networks in Parkinson's disease. ''CNS Neurosci Ther''. 2023 Jul; '''29''' (7):1907-1922
Blood transcriptomic signatures associated with molecular changes in the brain and clinical outcomes in Parkinson's disease.
Description: Irmady, Krithi, et al. Blood transcriptomic signatures associated with molecular changes in the brain and clinical outcomes in Parkinson's disease. ''Nat Commun''. 2023 Jul 5; '''14''' (1):3956
A beginner's guide into curated analyses of open access datasets for biomarker discovery in neurodegeneration.
Description: Gomes Moreira, Diana, et al. A beginner's guide into curated analyses of open access datasets for biomarker discovery in neurodegeneration. ''Sci Data''. 2023 Jul 6; '''10''' (1):432
Proteome wide association studies of LRRK2 variants identify novel causal and druggable proteins for Parkinson's disease.
Description: Phillips, Bridget, et al. Proteome wide association studies of LRRK2 variants identify novel causal and druggable proteins for Parkinson's disease. ''NPJ Parkinsons Dis''. 2023 Jul 8; '''9''' (1):107
Two distinct trajectories of clinical and neurodegeneration events in Parkinson's disease.
Description: Zhou, Cheng, et al. Two distinct trajectories of clinical and neurodegeneration events in Parkinson's disease. ''NPJ Parkinsons Dis''. 2023 Jul 13; '''9''' (1):111
Current coffee consumption is associated with decreased striatal dopamine transporter availability in Parkinson's disease patients and healthy controls.
Description: Wang, Chao, et al. Current coffee consumption is associated with decreased striatal dopamine transporter availability in Parkinson's disease patients and healthy controls. ''BMC Med''. 2023 Jul 25; '''21''' (1):272
Longitudinal cognitive changes in patients with early Parkinson's disease and neuropsychiatric symptoms.
Description: Meng, Detao, et al. Longitudinal cognitive changes in patients with early Parkinson's disease and neuropsychiatric symptoms. ''CNS Neurosci Ther''. 2023 Aug; '''29''' (8):2259-2266
Mitochondrial function-associated genes underlie cortical atrophy in prodromal synucleinopathies.
Description: Rahayel, Shady, et al. Mitochondrial function-associated genes underlie cortical atrophy in prodromal synucleinopathies. ''Brain''. 2023 Aug 1; '''146''' (8):3301-3318
Machine learning-based prediction of longitudinal cognitive decline in early Parkinson's disease using multimodal features.
Description: Almgren, Hannes, et al. Machine learning-based prediction of longitudinal cognitive decline in early Parkinson's disease using multimodal features. ''Sci Rep''. 2023 Aug 14; '''13''' (1):13193
Nigral volume loss in prodromal, early, and moderate Parkinson's disease.
Description: Langley, Jason, et al. Nigral volume loss in prodromal, early, and moderate Parkinson's disease. ''medRxiv''. 2023 Aug 20;
Reference LINE-1 insertion polymorphisms correlate with Parkinson's disease progression and differential transcript expression in the PPMI cohort.
Description: Frohlich, Alexander, et al. Reference LINE-1 insertion polymorphisms correlate with Parkinson's disease progression and differential transcript expression in the PPMI cohort. ''Sci Rep''. 2023 Aug 24; '''13''' (1):13857
The combined effect of lifestyle factors and polygenic scores on age at onset in Parkinson's disease.
Description: Gabbert, Carolin, et al. The combined effect of lifestyle factors and polygenic scores on age at onset in Parkinson's disease. ''medRxiv''. 2023 Aug 25;
Classification of Parkinson's Disease in Patch-Based MRI of Substantia Nigra.
Description: Hussain, Sayyed Shahid, et al. Classification of Parkinson's Disease in Patch-Based MRI of Substantia Nigra. ''Diagnostics (Basel)''. 2023 Aug 31; '''13''' (17):
Alternative splicing impacts microRNA regulation within coding regions.
Description: Hackl, Lena Maria, et al. Alternative splicing impacts microRNA regulation within coding regions. ''NAR Genom Bioinform''. 2023 Sep; '''5''' (3):lqad081
An Individualized Tractography Pipeline for the Nucleus Basalis of Meynert Lateral Tract.
Description: Crockett, Rachel A, et al. An Individualized Tractography Pipeline for the Nucleus Basalis of Meynert Lateral Tract. ''medRxiv''. 2023 Sep 1;
No laughing white matter: Reduced integrity of the cortical cholinergic pathways in Parkinson's disease-related cognitive impairment.
Description: Crockett, Rachel A, et al. No laughing white matter: Reduced integrity of the cortical cholinergic pathways in Parkinson's disease-related cognitive impairment. ''Neurobiol Dis''. 2023 Sep; '''185''': 106243
The effects of AQP4 rs162009 on resting-state brain activity in Parkinson's disease.
Description: Jiang, Mengze, et al. The effects of AQP4 rs162009 on resting-state brain activity in Parkinson's disease. ''CNS Neurosci Ther''. 2023 Sep; '''29''' (9):2645-2655
Autonomic function and motor subtypes in Parkinson's disease: a multicentre cross-sectional study.
Description: Gu, Si-Chun, et al. Autonomic function and motor subtypes in Parkinson's disease: a multicentre cross-sectional study. ''Sci Rep''. 2023 Sep 4; '''13''' (1):14548
Neurofilament light chain as a mediator between LRRK2 mutation and dementia in Parkinson's disease.
Description: Yang, Dehao, et al. Neurofilament light chain as a mediator between LRRK2 mutation and dementia in Parkinson's disease. ''NPJ Parkinsons Dis''. 2023 Sep 12; '''9''' (1):132
CSF proteome profiling reveals biomarkers to discriminate dementia with Lewy bodies from Alzheimer s disease.
Description: Del Campo, Marta, et al. CSF proteome profiling reveals biomarkers to discriminate dementia with Lewy bodies from Alzheimer s disease. ''Nat Commun''. 2023 Sep 13; '''14''' (1):5635
Dopamine pathway and Parkinson's risk variants are associated with levodopa-induced dyskinesia.
Description: Sosero, Yuri L, et al. Dopamine pathway and Parkinson's risk variants are associated with levodopa-induced dyskinesia. ''medRxiv''. 2023 Sep 20;
Invasive neurophysiology and whole brain connectomics for neural decoding in patients with brain implants.
Description: Merk, Timon, et al. Invasive neurophysiology and whole brain connectomics for neural decoding in patients with brain implants. ''Res Sq''. 2023 Sep 20;
Genetics of NLRP3 suggests lack of involvement and inefficient druggability in Parkinson's disease.
Description: Senkevich, Konstantin, et al. Genetics of NLRP3 suggests lack of involvement and inefficient druggability in Parkinson's disease. ''medRxiv''. 2023 Sep 23;
Patient-specific models link neurotransmitter receptor mechanisms with motor and visuospatial axes of Parkinson's disease.
Description: Khan, Ahmed Faraz, et al. Patient-specific models link neurotransmitter receptor mechanisms with motor and visuospatial axes of Parkinson's disease. ''Nat Commun''. 2023 Sep 26; '''14''' (1):6009
Association of coffee consumption and striatal volume in patients with Parkinson's disease and healthy controls.
Description: Wang, Chao, et al. Association of coffee consumption and striatal volume in patients with Parkinson's disease and healthy controls. ''CNS Neurosci Ther''. 2023 Oct; '''29''' (10):2800-2810
Longitudinal decline in striatal dopamine transporter binding in Parkinson's disease: associations with apathy and anhedonia.
Description: Costello, Harry, et al. Longitudinal decline in striatal dopamine transporter binding in Parkinson's disease: associations with apathy and anhedonia. ''J Neurol Neurosurg Psychiatry''. 2023 Oct; '''94''' (10):863-870
Parallel neurodegenerative phenotypes in sporadic Parkinson's disease fibroblasts and midbrain dopamine neurons.
Description: Corenblum, M J, et al. Parallel neurodegenerative phenotypes in sporadic Parkinson's disease fibroblasts and midbrain dopamine neurons. ''Prog Neurobiol''. 2023 Oct; '''229''': 102501
Style transfer generative adversarial networks to harmonize multisite MRI to a single reference image to avoid overcorrection.
Description: Liu, Mengting, et al. Style transfer generative adversarial networks to harmonize multisite MRI to a single reference image to avoid overcorrection. ''Hum Brain Mapp''. 2023 Oct 1; '''44''' (14):4875-4892
Effects of MRI scanner manufacturers in classification tasks with deep learning models.
Description: Kushol, Rafsanjany, et al. Effects of MRI scanner manufacturers in classification tasks with deep learning models. ''Sci Rep''. 2023 Oct 5; '''13''' (1):16791
Predicting cognitive decline in a low-dimensional representation of brain morphology.
Description: Lamontagne-Caron, Remi, et al. Predicting cognitive decline in a low-dimensional representation of brain morphology. ''Sci Rep''. 2023 Oct 5; '''13''' (1):16793
Federated Learning for multi-omics: a performance evaluation in Parkinson's disease.
Description: Danek, Benjamin, et al. Federated Learning for multi-omics: a performance evaluation in Parkinson's disease. ''bioRxiv''. 2023 Oct 6;
Salience network and cognitive impairment in Parkinson's disease.
Description: Yeager, Brooke E, et al. Salience network and cognitive impairment in Parkinson's disease. ''medRxiv''. 2023 Oct 14;
MRI-based multivariate gray matter volumetric distance for predicting motor symptom progression in Parkinson's disease.
Description: Vijayakumari, Anupa A, et al. MRI-based multivariate gray matter volumetric distance for predicting motor symptom progression in Parkinson's disease. ''Sci Rep''. 2023 Oct 17; '''13''' (1):17704
Urinary incontinence-related effects on functional connectivity circuits in persons with Parkinson's disease.
Description: Denmon, Chanse, et al. Urinary incontinence-related effects on functional connectivity circuits in persons with Parkinson's disease. ''Neurourol Urodyn''. 2023 Nov; '''42''' (8):1694-1701
The Parkinson's disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons.
Description: Jones-Tabah, Jace, et al. The Parkinson's disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons. ''bioRxiv''. 2023 Nov 15;
Traveling Subject-Informed Harmonization Increases Reliability of Brain Diffusion Tensor and Neurite Mapping.
Description: Saito, Yuya, et al. Traveling Subject-Informed Harmonization Increases Reliability of Brain Diffusion Tensor and Neurite Mapping. ''Aging Dis''. 2023 Nov 15; '''15''' (6):2770-2785
Association between the blood pressure variability and cognitive decline in Parkinson's disease.
Description: Xiao, Yi, et al. Association between the blood pressure variability and cognitive decline in Parkinson's disease. ''Brain Behav''. 2023 Dec; '''13''' (12):e3319
Lifespan neurodegeneration of the human brain in multiple sclerosis.
Description: Coupe, Pierrick, et al. Lifespan neurodegeneration of the human brain in multiple sclerosis. ''Hum Brain Mapp''. 2023 Dec 1; '''44''' (17):5602-5611
Predictors of dopamine dysregulation syndrome in patients with early Parkinson's disease.
Description: Liang, Keke, et al. Predictors of dopamine dysregulation syndrome in patients with early Parkinson's disease. ''Neurol Sci''. 2023 Dec; '''44''' (12):4333-4342
Seed amplification assay results illustrate discrepancy in Parkinson's disease clinical diagnostic accuracy and error rates.
Description: Middleton, John Stephen, et al. Seed amplification assay results illustrate discrepancy in Parkinson's disease clinical diagnostic accuracy and error rates. ''J Neurol''. 2023 Dec; '''270''' (12):5813-5818
Structural connectivity from DTI to predict mild cognitive impairment in de novo Parkinson's disease.
Description: Huang, Xiaofei, et al. Structural connectivity from DTI to predict mild cognitive impairment in de novo Parkinson's disease. ''Neuroimage Clin''. 2023 Dec 2; '''41''': 103548
Prediction of dyskinesia in Parkinson's disease patients using machine learning algorithms.
Description: Leal, Denisson Augusto Bastos, et al. Prediction of dyskinesia in Parkinson's disease patients using machine learning algorithms. ''Sci Rep''. 2023 Dec 16; '''13''' (1):22426
A multi-center distributed learning approach for Parkinson's disease classification using the traveling model paradigm.
Description: Souza, Raissa, et al. A multi-center distributed learning approach for Parkinson's disease classification using the traveling model paradigm. ''Front Artif Intell''. 2024; '''7''': 1301997
An individualized tractography pipeline for the nucleus basalis of Meynert lateral tract.
Description: Crockett, Rachel A, et al. An individualized tractography pipeline for the nucleus basalis of Meynert lateral tract. ''Imaging Neurosci (Camb)''. 2024; '''2''':
Assessment tools for cognitive performance in Parkinson's disease and its genetic contributors.
Description: Cao, Ling-Xiao, et al. Assessment tools for cognitive performance in Parkinson's disease and its genetic contributors. ''Front Neurol''. 2024; '''15''': 1413187
A systematic review of automated methods to perform white matter tract segmentation.
Description: Joshi, Ankita, et al. A systematic review of automated methods to perform white matter tract segmentation. ''Front Neurosci''. 2024; '''18''': 1376570
Comparison between morphometry and radiomics: detecting normal brain aging based on grey matter.
Description: Yan, Yuting, et al. Comparison between morphometry and radiomics: detecting normal brain aging based on grey matter. ''Front Aging Neurosci''. 2024; '''16''': 1366780
Cortical and subcortical functional connectivity and cognitive impairment in Parkinson's disease.
Description: Yeager, Brooke E, et al. Cortical and subcortical functional connectivity and cognitive impairment in Parkinson's disease. ''Neuroimage Clin''. 2024; '''42''': 103610
DiMANI: diffusion MRI for anatomical nuclei imaging-Application for the direct visualization of thalamic subnuclei.
Description: Patriat, Remi, et al. DiMANI: diffusion MRI for anatomical nuclei imaging-Application for the direct visualization of thalamic subnuclei. ''Front Hum Neurosci''. 2024; '''18''': 1324710
Excessive Daytime Sleepiness as a Risk Factor for Impulse Control Disorders in Parkinson's Disease.
Description: Tang, Xiaohui, et al. Excessive Daytime Sleepiness as a Risk Factor for Impulse Control Disorders in Parkinson's Disease. ''Neuropsychiatr Dis Treat''. 2024; '''20''': 2517-2527
Exploring the layers of fatigue in Parkinson's Disease: A comprehensive analysis of its prevalence and contributing factors.
Description: Exploring the layers of fatigue in Parkinson's Disease: A comprehensive analysis of its prevalence and contributing factors. ''''. 2024; '''11''': 100288
Exposure to household pesticides and Parkinson's disease in the Parkinson's Progression Markers Initiative cohort.
Description: Santos-Lobato, Bruno Lopes, et al. Exposure to household pesticides and Parkinson's disease in the Parkinson's Progression Markers Initiative cohort. ''Front Neurol''. 2024; '''15''': 1411468
Fine-grained features characterize hippocampal and amygdaloid change pattern in Parkinson's disease and discriminate cognitive-deficit subtype.
Description: Zhang, Lingyu, et al. Fine-grained features characterize hippocampal and amygdaloid change pattern in Parkinson's disease and discriminate cognitive-deficit subtype. ''CNS Neurosci Ther''. 2024 Jan; '''30''' (1):e14480
Identification of Parkinson's disease subtypes with distinct brain atrophy progression and its association with clinical progression.
Description: Pan, Guoqing, et al. Identification of Parkinson's disease subtypes with distinct brain atrophy progression and its association with clinical progression. ''Psychoradiology''. 2024; '''4''': kkae002
Inferring neurocognition using artificial intelligence on brain MRIs.
Description: Hussain, Mohammad Arafat, et al. Inferring neurocognition using artificial intelligence on brain MRIs. ''Front Neuroimaging''. 2024; '''3''': 1455436
Iron deposition is associated with motor and non-motor network breakdown in parkinsonism.
Description: Leng, Fangda, et al. Iron deposition is associated with motor and non-motor network breakdown in parkinsonism. ''Front Aging Neurosci''. 2024; '''16''': 1518155
Longitudinal brain structure changes in Parkinson's disease: A replication study.
Description: Sokolowski, Andrzej, et al. Longitudinal brain structure changes in Parkinson's disease: A replication study. ''PLoS One''. 2024; '''19''' (1):e0295069
Microstructural alterations in white matter and related neurobiology based on the new clinical subtypes of Parkinson's disease.
Description: Yuan, Xiaorong, et al. Microstructural alterations in white matter and related neurobiology based on the new clinical subtypes of Parkinson's disease. ''Front Neurosci''. 2024; '''18''': 1439443
Modeling of Parkinson's Disease Progression and Implications for Detection of Disease Modification in Treatment Trials.
Description: Ribba, Benjamin, et al. Modeling of Parkinson's Disease Progression and Implications for Detection of Disease Modification in Treatment Trials. ''J Parkinsons Dis''. 2024; '''14''' (6):1225-1235
Motor dysfunction in Parkinson's patients: depression differences in a latent growth model.
Description: Wang, QiuShuang, et al. Motor dysfunction in Parkinson's patients: depression differences in a latent growth model. ''Front Aging Neurosci''. 2024; '''16''': 1393887
Multiomics analysis identifies novel facilitators of human dopaminergic neuron differentiation.
Description: Gomez Ramos, Borja, et al. Multiomics analysis identifies novel facilitators of human dopaminergic neuron differentiation. ''EMBO Rep''. 2024 Jan; '''25''' (1):254-285
Occupational Pesticide Exposure in Parkinson's Disease Related to GBA and LRRK2 Variants.
Description: Brown, Ethan G, et al. Occupational Pesticide Exposure in Parkinson's Disease Related to GBA and LRRK2 Variants. ''J Parkinsons Dis''. 2024; '''14''' (4):737-746
Predicting the occurrence of mild cognitive impairment in Parkinson's disease using structural MRI data.
Description: Beheshti, Iman, et al. Predicting the occurrence of mild cognitive impairment in Parkinson's disease using structural MRI data. ''Front Neurosci''. 2024; '''18''': 1375395
Regulatory SVA retrotransposons and classical HLA genotyped-transcripts associated with Parkinson's disease.
Description: Kulski, Jerzy K, et al. Regulatory SVA retrotransposons and classical HLA genotyped-transcripts associated with Parkinson's disease. ''Front Immunol''. 2024; '''15''': 1349030
SNPs in cytochromes P450 catalyzing cholesterol degradation in brain are associated with Parkinson's disease.
Description: Petkova-Kirova, Polina, et al. SNPs in cytochromes P450 catalyzing cholesterol degradation in brain are associated with Parkinson's disease. ''Front Pharmacol''. 2024; '''15''': 1477009
Sparse Deep Neural Network for Encoding and Decoding the Structural Connectome.
Description: Singh, Satya P, et al. Sparse Deep Neural Network for Encoding and Decoding the Structural Connectome. ''IEEE J Transl Eng Health Med''. 2024; '''12''': 371-381
Staging of progressive supranuclear palsy-Richardson syndrome using MRI brain charts for the human lifespan.
Description: Planche, Vincent, et al. Staging of progressive supranuclear palsy-Richardson syndrome using MRI brain charts for the human lifespan. ''Brain Commun''. 2024; '''6''' (2):fcae055
Temporal evolution of microstructural integrity in cerebellar peduncles in Parkinson's disease: Stage-specific patterns and dopaminergic correlates.
Description: He, Chentao, et al. Temporal evolution of microstructural integrity in cerebellar peduncles in Parkinson's disease: Stage-specific patterns and dopaminergic correlates. ''Neuroimage Clin''. 2024; '''44''': 103679
The association of motor reserve and clinical progression in Parkinson's disease.
Description: Bai, Xueqin, et al. The association of motor reserve and clinical progression in Parkinson's disease. ''Neuroimage Clin''. 2024; '''44''': 103704
Proxy-analysis of the genetics of cognitive decline in Parkinson's disease through polygenic scores.
Description: Faouzi, Johann, et al. Proxy-analysis of the genetics of cognitive decline in Parkinson's disease through polygenic scores. ''NPJ Parkinsons Dis''. 2024 Jan 4; '''10''' (1):8
Radiomic tractometry reveals tract-specific imaging biomarkers in white matter.
Description: Neher, Peter, et al. Radiomic tractometry reveals tract-specific imaging biomarkers in white matter. ''Nat Commun''. 2024 Jan 5; '''15''' (1):303
A SINE-VNTR-Alu at the LRIG2 locus is associated with proximal and distal gene expression in CRISPR and population models.
Description: Hall, Ashley, et al. A SINE-VNTR-Alu at the LRIG2 locus is associated with proximal and distal gene expression in CRISPR and population models. ''Sci Rep''. 2024 Jan 8; '''14''' (1):792
Immunological shifts during early-stage Parkinson's disease identified with DNA methylation data on longitudinally collected blood samples.
Description: Pike, Steven C, et al. Immunological shifts during early-stage Parkinson's disease identified with DNA methylation data on longitudinally collected blood samples. ''NPJ Parkinsons Dis''. 2024 Jan 11; '''10''' (1):21
Early-stage idiopathic Parkinson's disease is associated with reduced circular RNA expression.
Description: Whittle, Benjamin J, et al. Early-stage idiopathic Parkinson's disease is associated with reduced circular RNA expression. ''NPJ Parkinsons Dis''. 2024 Jan 20; '''10''' (1):25
MerTK is a mediator of alpha-synuclein fibril uptake by human microglia.
Description: Dorion, Marie-France, et al. MerTK is a mediator of alpha-synuclein fibril uptake by human microglia. ''Brain''. 2024 Feb 1; '''147''' (2):427-443
Differences in brain aging between sexes in Parkinson's disease.
Description: Beheshti, Iman, et al. Differences in brain aging between sexes in Parkinson's disease. ''NPJ Parkinsons Dis''. 2024 Feb 14; '''10''' (1):35
Deep learning-based BMI inference from structural brain MRI reflects brain alterations following lifestyle intervention.
Description: Finkelstein, Ofek, et al. Deep learning-based BMI inference from structural brain MRI reflects brain alterations following lifestyle intervention. ''Hum Brain Mapp''. 2024 Feb 15; '''45''' (3):e26595
Rare and common genetic determinants of mitochondrial function determine severity but not risk of amyotrophic lateral sclerosis.
Description: Rare and common genetic determinants of mitochondrial function determine severity but not risk of amyotrophic lateral sclerosis. ''''. 2024 Feb 15; '''10''' (3):e24975
African ancestry neurodegeneration risk variant disrupts an intronic branchpoint in GBA1.
Description: Jerez, Pilar Alvarez, et al. African ancestry neurodegeneration risk variant disrupts an intronic branchpoint in GBA1. ''medRxiv''. 2024 Feb 24;
Assessing methylation detection for primary human tissue using Nanopore sequencing.
Description: Genner, Rylee, et al. Assessing methylation detection for primary human tissue using Nanopore sequencing. ''bioRxiv''. 2024 Mar 1;
Correlation of slow-wave sleep with motor and nonmotor progression in Parkinson's disease.
Description: Chen, Jing, et al. Correlation of slow-wave sleep with motor and nonmotor progression in Parkinson's disease. ''Ann Clin Transl Neurol''. 2024 Mar; '''11''' (3):554-563
Lifespan reference curves for harmonizing multi-site regional brain white matter metrics from diffusion MRI.
Description: Zhu, Alyssa H, et al. Lifespan reference curves for harmonizing multi-site regional brain white matter metrics from diffusion MRI. ''bioRxiv''. 2024 Mar 1;
Machine learning nominates the inositol pathway and novel genes in Parkinson's disease.
Description: Yu, Eric, et al. Machine learning nominates the inositol pathway and novel genes in Parkinson's disease. ''Brain''. 2024 Mar 1; '''147''' (3):887-899
Mapping dysfunctional circuits in the frontal cortex using deep brain stimulation.
Description: Hollunder, Barbara, et al. Mapping dysfunctional circuits in the frontal cortex using deep brain stimulation. ''Nat Neurosci''. 2024 Mar; '''27''' (3):573-586
Distinctive whole-brain cell types predict tissue damage patterns in thirteen neurodegenerative conditions.
Description: Pak, Veronika, et al. Distinctive whole-brain cell types predict tissue damage patterns in thirteen neurodegenerative conditions. ''Elife''. 2024 Mar 21; '''12''':
Automated identification of uncertain cases in deep learning-based classification of dopamine transporter SPECT to improve clinical utility and acceptance.
Description: Budenkotte, Thomas, et al. Automated identification of uncertain cases in deep learning-based classification of dopamine transporter SPECT to improve clinical utility and acceptance. ''Eur J Nucl Med Mol Imaging''. 2024 Apr; '''51''' (5):1333-1344
Data-driven disease progression model of Parkinson's disease and effect of sex and genetic variants.
Description: Jin, Ryota, et al. Data-driven disease progression model of Parkinson's disease and effect of sex and genetic variants. ''CPT Pharmacometrics Syst Pharmacol''. 2024 Apr; '''13''' (4):649-659
An adapted protocol to derive microglia from stem cells and its application in the study of CSF1R-related disorders.
Description: Dorion, Marie-France, et al. An adapted protocol to derive microglia from stem cells and its application in the study of CSF1R-related disorders. ''Mol Neurodegener''. 2024 Apr 5; '''19''' (1):31
A decision support system based on recurrent neural networks to predict medication dosage for patients with Parkinson's disease.
Description: Riasi, Atiye, et al. A decision support system based on recurrent neural networks to predict medication dosage for patients with Parkinson's disease. ''Sci Rep''. 2024 Apr 10; '''14''' (1):8424
Lysosomal genes contribute to Parkinson's disease near agriculture with high intensity pesticide use.
Description: Ngo, Kathie J, et al. Lysosomal genes contribute to Parkinson's disease near agriculture with high intensity pesticide use. ''NPJ Parkinsons Dis''. 2024 Apr 25; '''10''' (1):87
Longitudinal study investigating the influence of COMT gene polymorphism on cortical thickness changes in Parkinson's disease over four years.
Description: Tajerian, Amin. Longitudinal study investigating the influence of COMT gene polymorphism on cortical thickness changes in Parkinson's disease over four years. ''Sci Rep''. 2024 Apr 30; '''14''' (1):9920
Progression subtypes in Parkinson's disease identified by a data-driven multi cohort analysis.
Description: Hahnel, Tom, et al. Progression subtypes in Parkinson's disease identified by a data-driven multi cohort analysis. ''NPJ Parkinsons Dis''. 2024 May 2; '''10''' (1):95
Structural underpinnings and long-term effects of resilience in Parkinson's disease.
Description: Dzialas, Verena, et al. Structural underpinnings and long-term effects of resilience in Parkinson's disease. ''NPJ Parkinsons Dis''. 2024 May 2; '''10''' (1):94
Deciphering the role of a SINE-VNTR-Alu retrotransposon polymorphism as a biomarker of Parkinson's disease progression.
Description: Frohlich, Alexander, et al. Deciphering the role of a SINE-VNTR-Alu retrotransposon polymorphism as a biomarker of Parkinson's disease progression. ''Sci Rep''. 2024 May 13; '''14''' (1):10932
Profiling complex repeat expansions in RFC1 in Parkinson's disease.
Description: Alvarez Jerez, Pilar, et al. Profiling complex repeat expansions in RFC1 in Parkinson's disease. ''NPJ Parkinsons Dis''. 2024 May 24; '''10''' (1):108
Digital outcome measures from smartwatch data relate to non-motor features of Parkinson's disease.
Description: Schalkamp, Ann-Kathrin, et al. Digital outcome measures from smartwatch data relate to non-motor features of Parkinson's disease. ''NPJ Parkinsons Dis''. 2024 May 29; '''10''' (1):110
Are rare heterozygous SYNJ1 variants associated with Parkinson's disease?
Description: Senkevich, Konstantin, et al. Are rare heterozygous SYNJ1 variants associated with Parkinson's disease? ''medRxiv''. 2024 Jun 1;
Atrophy patterns in hippocampus and amygdala subregions of depressed patients with Parkinson's disease.
Description: Qu, Mingrui, et al. Atrophy patterns in hippocampus and amygdala subregions of depressed patients with Parkinson's disease. ''Brain Imaging Behav''. 2024 Jun; '''18''' (3):475-484
Left corticospinal tract could be a biomarker to identify the dual prodromal LRRK2/GBA mutated Parkinson's disease.
Description: Lin, Fabin, et al. Left corticospinal tract could be a biomarker to identify the dual prodromal LRRK2/GBA mutated Parkinson's disease. ''CNS Neurosci Ther''. 2024 Jun; '''30''' (6):e14728
Genome-wide association study of glucocerebrosidase activity modifiers.
Description: Somerville, Emma N, et al. Genome-wide association study of glucocerebrosidase activity modifiers. ''Res Sq''. 2024 Jun 7;
Genome-wide determinants of mortality and motor progression in Parkinson's disease.
Description: Tan, Manuela M X, et al. Genome-wide determinants of mortality and motor progression in Parkinson's disease. ''NPJ Parkinsons Dis''. 2024 Jun 7; '''10''' (1):113
Neuroanatomical Signature of the Transition from Normal Cognition to MCI in Parkinson's Disease.
Description: Beheshti, Iman, et al. Neuroanatomical Signature of the Transition from Normal Cognition to MCI in Parkinson's Disease. ''Aging Dis''. 2024 Jun 7; '''16''' (1):619-32
Unlocking the potential: T1-weighed MRI as a powerful predictor of levodopa response in Parkinson's disease.
Description: Yan, Junyi, et al. Unlocking the potential: T1-weighed MRI as a powerful predictor of levodopa response in Parkinson's disease. ''Insights Imaging''. 2024 Jun 9; '''15''' (1):141
DOPA-decarboxylase is elevated in CSF, but not plasma, in prodromal and de novo Parkinson's disease.
Description: Appleton, Ellen, et al. DOPA-decarboxylase is elevated in CSF, but not plasma, in prodromal and de novo Parkinson's disease. ''Transl Neurodegener''. 2024 Jun 11; '''13''' (1):31
Neuroimaging epicenters as potential sites of onset of the neuroanatomical pathology in schizophrenia.
Description: Jiang, Yuchao, et al. Neuroimaging epicenters as potential sites of onset of the neuroanatomical pathology in schizophrenia. ''Sci Adv''. 2024 Jun 14; '''10''' (24):eadk6063
Understanding the role of cerebellum in early Parkinson's disease: a structural and functional MRI study.
Description: Pietracupa, S, et al. Understanding the role of cerebellum in early Parkinson's disease: a structural and functional MRI study. ''NPJ Parkinsons Dis''. 2024 Jun 19; '''10''' (1):119
An improved method for diagnosis of Parkinson's disease using deep learning models enhanced with metaheuristic algorithm.
Description: Majhi, Babita, et al. An improved method for diagnosis of Parkinson's disease using deep learning models enhanced with metaheuristic algorithm. ''BMC Med Imaging''. 2024 Jun 24; '''24''' (1):156
Associations of cholinergic system integrity with cognitive decline in GBA1 and LRRK2 mutation carriers.
Description: Schumacher, Julia, et al. Associations of cholinergic system integrity with cognitive decline in GBA1 and LRRK2 mutation carriers. ''NPJ Parkinsons Dis''. 2024 Jun 29; '''10''' (1):127
Increased mean diffusivity of the caudal motor SNc identifies patients with REM sleep behaviour disorder and Parkinson's disease.
Description: Alushaj, Erind, et al. Increased mean diffusivity of the caudal motor SNc identifies patients with REM sleep behaviour disorder and Parkinson's disease. ''NPJ Parkinsons Dis''. 2024 Jun 29; '''10''' (1):128
Profiling people with Parkinson's disease at risk of cognitive decline: Insights from PPMI and ICICLE-PD data.
Description: Pourzinal, Dana, et al. Profiling people with Parkinson's disease at risk of cognitive decline: Insights from PPMI and ICICLE-PD data. ''Alzheimers Dement (Amst)''. 2024 Jul-Sep; '''16''' (3):e12625
Sleep disturbances, cognitive decline, and AD biomarkers alterations in early Parkinson's disease.
Description: Zhong, Rui, et al. Sleep disturbances, cognitive decline, and AD biomarkers alterations in early Parkinson's disease. ''Ann Clin Transl Neurol''. 2024 Jul; '''11''' (7):1831-1839
Identification of Parkinson's disease PACE subtypes and repurposing treatments through integrative analyses of multimodal data.
Description: Su, Chang, et al. Identification of Parkinson's disease PACE subtypes and repurposing treatments through integrative analyses of multimodal data. ''NPJ Digit Med''. 2024 Jul 9; '''7''' (1):184
Radiomics incorporating deep features for predicting Parkinson's disease in (123)I-Ioflupane SPECT.
Description: Jiang, Han, et al. Radiomics incorporating deep features for predicting Parkinson's disease in (123)I-Ioflupane SPECT. ''EJNMMI Phys''. 2024 Jul 10; '''11''' (1):60
LRRK2-Associated Parkinsonism With and Without In Vivo Evidence of Alpha-Synuclein Aggregates.
Description: Chahine, Lana M, et al. LRRK2-Associated Parkinsonism With and Without In Vivo Evidence of Alpha-Synuclein Aggregates. ''medRxiv''. 2024 Jul 22;
Parkinson's disease psychosis associated with accelerated multidomain cognitive decline.
Description: Pisani, Sara, et al. Parkinson's disease psychosis associated with accelerated multidomain cognitive decline. ''BMJ Ment Health''. 2024 Jul 23; '''27''' (1):1-10
Characterizing a complex CT-rich haplotype in intron 4 of SNCA using large-scale targeted amplicon long-read sequencing.
Description: Alvarez Jerez, Pilar, et al. Characterizing a complex CT-rich haplotype in intron 4 of SNCA using large-scale targeted amplicon long-read sequencing. ''NPJ Parkinsons Dis''. 2024 Jul 26; '''10''' (1):136
Motor progression trajectories and risk of mild cognitive impairment in Parkinson's disease: A latent class trajectory model from PPMI cohort.
Description: Chen, Xi, et al. Motor progression trajectories and risk of mild cognitive impairment in Parkinson's disease: A latent class trajectory model from PPMI cohort. ''CNS Neurosci Ther''. 2024 Aug; '''30''' (8):e14918
Transcriptomics and weighted protein network analyses of the LRRK2 protein interactome reveal distinct molecular signatures for sporadic and LRRK2 Parkinson's Disease.
Description: Zhao, Yibo, et al. Transcriptomics and weighted protein network analyses of the LRRK2 protein interactome reveal distinct molecular signatures for sporadic and LRRK2 Parkinson's Disease. ''NPJ Parkinsons Dis''. 2024 Aug 3; '''10''' (1):144
Lack of genetic evidence for NLRP3 inflammasome involvement in Parkinson's disease pathogenesis.
Description: Senkevich, Konstantin, et al. Lack of genetic evidence for NLRP3 inflammasome involvement in Parkinson's disease pathogenesis. ''NPJ Parkinsons Dis''. 2024 Aug 5; '''10''' (1):145
Contrastive machine learning reveals Parkinson's disease specific features associated with disease severity and progression.
Description: Zheng, Liping, et al. Contrastive machine learning reveals Parkinson's disease specific features associated with disease severity and progression. ''Commun Biol''. 2024 Aug 7; '''7''' (1):954
A worldwide study of white matter microstructural alterations in people living with Parkinson's disease.
Description: Owens-Walton, Conor, et al. A worldwide study of white matter microstructural alterations in people living with Parkinson's disease. ''NPJ Parkinsons Dis''. 2024 Aug 11; '''10''' (1):151
Loss-of-function variants in ITSN1 confer high risk of Parkinson's disease.
Description: Skuladottir, Astros Th, et al. Loss-of-function variants in ITSN1 confer high risk of Parkinson's disease. ''NPJ Parkinsons Dis''. 2024 Aug 15; '''10''' (1):140
MRI subtypes in Parkinson's disease across diverse populations and clustering approaches.
Description: Inguanzo, Anna, et al. MRI subtypes in Parkinson's disease across diverse populations and clustering approaches. ''NPJ Parkinsons Dis''. 2024 Aug 16; '''10''' (1):159
Shared and distinct cortical morphometric alterations in five neuropsychiatric symptoms of Parkinson's disease.
Description: Lu, Qianling, et al. Shared and distinct cortical morphometric alterations in five neuropsychiatric symptoms of Parkinson's disease. ''Transl Psychiatry''. 2024 Aug 30; '''14''' (1):347
Multi-modality radiomics of conventional T1 weighted and diffusion tensor imaging for differentiating Parkinson's disease motor subtypes in early-stages.
Description: Panahi, Mehdi, et al. Multi-modality radiomics of conventional T1 weighted and diffusion tensor imaging for differentiating Parkinson's disease motor subtypes in early-stages. ''Sci Rep''. 2024 Sep 5; '''14''' (1):20708
Contrastive Graph Pooling for Explainable Classification of Brain Networks.
Description: Xu, Jiaxing, et al. Contrastive Graph Pooling for Explainable Classification of Brain Networks. ''ArXiv''. 2024 Sep 6;
Long-Term Dementia Risk in Parkinson Disease.
Description: Gallagher, Julia, et al. Long-Term Dementia Risk in Parkinson Disease. ''Neurology''. 2024 Sep 10; '''103''' (5):e209699
Neuronal alpha-Synuclein Disease Integrated Staging System performance in PPMI, PASADENA, and SPARK baseline cohorts.
Description: Dam, Tien, et al. Neuronal alpha-Synuclein Disease Integrated Staging System performance in PPMI, PASADENA, and SPARK baseline cohorts. ''medRxiv''. 2024 Sep 10;
Language Modeling Screens Parkinson's Disease with Self-reported Questionnaires.
Description: Reyes, Diego Machado, et al. Language Modeling Screens Parkinson's Disease with Self-reported Questionnaires. ''medRxiv''. 2024 Sep 24;
Neuronal alpha-Synuclein Disease integrated staging system performance in PPMI, PASADENA, and SPARK baseline cohorts.
Description: Dam, Tien, et al. Neuronal alpha-Synuclein Disease integrated staging system performance in PPMI, PASADENA, and SPARK baseline cohorts. ''NPJ Parkinsons Dis''. 2024 Sep 27; '''10''' (1):178
Blood-based multivariate methylation risk score for cognitive impairment and dementia.
Description: Koetsier, Jarno, et al. Blood-based multivariate methylation risk score for cognitive impairment and dementia. ''Alzheimers Dement''. 2024 Oct; '''20''' (10):6682-6698
Exploratory Analysis of the Association Between Plasma Ceramide Alterations and Cognitive Dysfunction in Parkinson's Disease.
Description: Liu, Xu, et al. Exploratory Analysis of the Association Between Plasma Ceramide Alterations and Cognitive Dysfunction in Parkinson's Disease. ''CNS Neurosci Ther''. 2024 Oct; '''30''' (10):e70082
Surface-Based Morphometry Analysis of the Cerebral Cortex in Patients With Probable Idiopathic Rapid Eye Movement Sleep Behavior Disorder.
Description: Najafzadeh, Milad, et al. Surface-Based Morphometry Analysis of the Cerebral Cortex in Patients With Probable Idiopathic Rapid Eye Movement Sleep Behavior Disorder. ''Brain Behav''. 2024 Oct; '''14''' (10):e70057
Medication recommendation for Parkinson's disease based on dynamics of symptom progression.
Description: Oh, Minjae, et al. Medication recommendation for Parkinson's disease based on dynamics of symptom progression. ''Sci Rep''. 2024 Oct 23; '''14''' (1):25051
Prediction, prognosis and monitoring of neurodegeneration at biobank-scale via machine learning and imaging.
Description: Dadu, Anant, et al. Prediction, prognosis and monitoring of neurodegeneration at biobank-scale via machine learning and imaging. ''medRxiv''. 2024 Oct 28;
RGS10 Attenuates Systemic Immune Dysregulation Induced by Chronic Inflammatory Stress.
Description: Jernigan, Janna E, et al. RGS10 Attenuates Systemic Immune Dysregulation Induced by Chronic Inflammatory Stress. ''bioRxiv''. 2024 Oct 29;
Validating new symptom emergence as a patient-centric outcome measure for PD clinical trials.
Description: Zou, Haotian, et al. Validating new symptom emergence as a patient-centric outcome measure for PD clinical trials. ''Parkinsonism Relat Disord''. 2024 Nov; '''128''': 107118
The effect of pallidal stimulation on sleep outcomes and related brain connectometries in Parkinson's disease.
Description: Zheng, Zhaoting, et al. The effect of pallidal stimulation on sleep outcomes and related brain connectometries in Parkinson's disease. ''NPJ Parkinsons Dis''. 2024 Nov 4; '''10''' (1):212
Peripheral immune cell abundance differences link blood mitochondrial DNA copy number and Parkinson's disease.
Description: Wang, Longfei, et al. Peripheral immune cell abundance differences link blood mitochondrial DNA copy number and Parkinson's disease. ''NPJ Parkinsons Dis''. 2024 Nov 14; '''10''' (1):219
Constructing and exploring neuroimaging projects: a survey from clinical practice to scientific research.
Description: Chen, Ziyan, et al. Constructing and exploring neuroimaging projects: a survey from clinical practice to scientific research. ''Insights Imaging''. 2024 Nov 15; '''15''' (1):272
Biobank-scale characterization of Alzheimer's disease and related dementias identifies potential disease-causing variants, risk factors, and genetic modifiers across diverse ancestries.
Description: Khani, Marzieh, et al. Biobank-scale characterization of Alzheimer's disease and related dementias identifies potential disease-causing variants, risk factors, and genetic modifiers across diverse ancestries. ''medRxiv''. 2024 Nov 17;
Circulating blood circular RNA in Parkinson's Disease; from involvement in pathology to diagnostic tools in at-risk individuals.
Description: Beric, Aleksandra, et al. Circulating blood circular RNA in Parkinson's Disease; from involvement in pathology to diagnostic tools in at-risk individuals. ''NPJ Parkinsons Dis''. 2024 Nov 18; '''10''' (1):222
Relative sparing of dopaminergic terminals in the caudate nucleus is a feature of rest tremor in Parkinson's disease.
Description: Mendonca, Marcelo D, et al. Relative sparing of dopaminergic terminals in the caudate nucleus is a feature of rest tremor in Parkinson's disease. ''NPJ Parkinsons Dis''. 2024 Nov 18; '''10''' (1):209
A worldwide study of subcortical shape as a marker for clinical staging in Parkinson's disease.
Description: Laansma, Max A, et al. A worldwide study of subcortical shape as a marker for clinical staging in Parkinson's disease. ''NPJ Parkinsons Dis''. 2024 Nov 19; '''10''' (1):223
Decreased SNCA Expression in Whole-Blood RNA Analysis of Parkinson's Disease Adjusting for Lymphocytes.
Description: Xu, Kayla, et al. Decreased SNCA Expression in Whole-Blood RNA Analysis of Parkinson's Disease Adjusting for Lymphocytes. ''bioRxiv''. 2024 Nov 19;
Longitudinal decline in DAT binding in Parkinson's disease: connections with sleep disturbances.
Description: Ren, Junli, et al. Longitudinal decline in DAT binding in Parkinson's disease: connections with sleep disturbances. ''BMC Med''. 2024 Nov 21; '''22''' (1):550
Personalized progression modelling and prediction in Parkinson's disease with a novel multi-modal graph approach.
Description: Lian, Jie, et al. Personalized progression modelling and prediction in Parkinson's disease with a novel multi-modal graph approach. ''NPJ Parkinsons Dis''. 2024 Dec 1; '''10''' (1):229
Sustained effect of prasinezumab on Parkinson's disease motor progression in the open-label extension of the PASADENA trial.
Description: Pagano, Gennaro, et al. Sustained effect of prasinezumab on Parkinson's disease motor progression in the open-label extension of the PASADENA trial. ''Nat Med''. 2024 Dec; '''30''' (12):3669-3675
Changes in Hippocampal Volume after Traumatic Brain Injury (TBI).
Description: Kriukova, Kseniia, et al. Changes in Hippocampal Volume after Traumatic Brain Injury (TBI). ''Res Sq''. 2024 Dec 4;
Impact of dopamine deficiency and REM sleep behavior disorder on cognition in early neuronal synuclein disease with hyposmia.
Description: Weintraub, Daniel, et al. Impact of dopamine deficiency and REM sleep behavior disorder on cognition in early neuronal synuclein disease with hyposmia. ''medRxiv''. 2024 Dec 13;
Approximating R1 and R2: A Quantitative Approach to Clinical Weighted MRI.
Description: Moskovich, Shachar, et al. Approximating R1 and R2: A Quantitative Approach to Clinical Weighted MRI. ''Hum Brain Mapp''. 2024 Dec 15; '''45''' (18):e70102
PINK1 is a target of T cell responses in Parkinson's disease.
Description: Williams, Gregory P, et al. PINK1 is a target of T cell responses in Parkinson's disease. ''J Clin Invest''. 2024 Dec 17; '''135''' (4):
Exploring the Potential Imaging Biomarkers for Parkinson's Disease Using Machine Learning Approach.
Description: Mushta, Illia, et al. Exploring the Potential Imaging Biomarkers for Parkinson's Disease Using Machine Learning Approach. ''Bioengineering (Basel)''. 2024 Dec 27; '''12''' (1):
Machine learning analysis of population-wide plasma proteins identifies hormonal biomarkers of Parkinson's Disease.
Description: Chaudhry, Fayzan, et al. Machine learning analysis of population-wide plasma proteins identifies hormonal biomarkers of Parkinson's Disease. ''medRxiv''. 2024 Dec 27;
A review of AI-based radiogenomics in neurodegenerative disease.
Description: Liu, Huanjing, et al. A review of AI-based radiogenomics in neurodegenerative disease. ''Front Big Data''. 2025; '''8''': 1515341
Association between serum sodium and sporadic Parkinson's disease.
Description: Zhou, Wen, et al. Association between serum sodium and sporadic Parkinson's disease. ''Front Neurosci''. 2025; '''19''': 1555831
Bidirectional relationship between depression and activities of daily living and longitudinal mediation of cognitive function in patients with Parkinson's disease.
Description: Xu, Yue, et al. Bidirectional relationship between depression and activities of daily living and longitudinal mediation of cognitive function in patients with Parkinson's disease. ''Front Aging Neurosci''. 2025; '''17''': 1513373
Brain structural MRI marker for predicting conversion to Parkinson's disease in individuals with prodromal symptoms.
Description: Park, Chang-Hyun, et al. Brain structural MRI marker for predicting conversion to Parkinson's disease in individuals with prodromal symptoms. ''Front Aging Neurosci''. 2025; '''17''': 1579326
Disrupted functional brain network associated with presence of hallucinations in Parkinson's disease.
Description: Montagnese, Marcella, et al. Disrupted functional brain network associated with presence of hallucinations in Parkinson's disease. ''Brain Commun''. 2025; '''7''' (3):fcaf185
Domain-Specific Prediction of Clinical Progression in Parkinson's Disease Using the Mosaic Approach.
Description: Tahedl, Marlene, et al. Domain-Specific Prediction of Clinical Progression in Parkinson's Disease Using the Mosaic Approach. ''Brain Behav''. 2025 Jan; '''15''' (1):e70289
Identification of Parkinson's disease using MRI and genetic data from the PPMI cohort: an improved machine learning fusion approach.
Description: Yang, Yifeng, et al. Identification of Parkinson's disease using MRI and genetic data from the PPMI cohort: an improved machine learning fusion approach. ''Front Aging Neurosci''. 2025; '''17''': 1510192
Longitudinal analysis of step counts in Parkinson's disease patients: insights from a web-based application and generalized additive model.
Description: Gu, Yuan, et al. Longitudinal analysis of step counts in Parkinson's disease patients: insights from a web-based application and generalized additive model. ''PeerJ''. 2025; '''13''': e19519
Longitudinal Assessment of Parkinson's Motor Symptoms and Dopaminergic Dysfunction Patterns Using DaTSCAN.
Description: Najmi, Amir Hossein, et al. Longitudinal Assessment of Parkinson's Motor Symptoms and Dopaminergic Dysfunction Patterns Using DaTSCAN. ''Clin Park Relat Disord''. 2025; '''12''': 100331
LRRK2-associated parkinsonism with and without in vivo evidence of alpha-synuclein aggregates: longitudinal clinical and biomarker characterization.
Description: Chahine, Lana M, et al. LRRK2-associated parkinsonism with and without in vivo evidence of alpha-synuclein aggregates: longitudinal clinical and biomarker characterization. ''Brain Commun''. 2025; '''7''' (2):fcaf103
Motor asymmetry in Parkinson's disease: Diagnostic thresholds based on clinical scores and DaTSCAN imaging.
Description: Voruz, Philippe, et al. Motor asymmetry in Parkinson's disease: Diagnostic thresholds based on clinical scores and DaTSCAN imaging. ''Clin Park Relat Disord''. 2025; '''12''': 100350
Multi-Center 3D CNN for Parkinson's disease diagnosis and prognosis using clinical and T1-weighted MRI data.
Description: Basaia, Silvia, et al. Multi-Center 3D CNN for Parkinson's disease diagnosis and prognosis using clinical and T1-weighted MRI data. ''Neuroimage Clin''. 2025; '''48''': 103859
Neuroimaging-based data-driven subtypes of spatiotemporal atrophy due to Parkinson's disease.
Description: Shawa, Zeena, et al. Neuroimaging-based data-driven subtypes of spatiotemporal atrophy due to Parkinson's disease. ''Brain Commun''. 2025; '''7''' (2):fcaf146
Predicting Parkinson's disease trajectory using clinical and functional MRI features: A reproduction and replication study.
Description: Germani, Elodie, et al. Predicting Parkinson's disease trajectory using clinical and functional MRI features: A reproduction and replication study. ''PLoS One''. 2025; '''20''' (2):e0317566
Rapid frontotemporal gray matter loss in proposed body-first Parkinson's disease: a longitudinal voxel-based morphometry study.
Description: Yan, Jin, et al. Rapid frontotemporal gray matter loss in proposed body-first Parkinson's disease: a longitudinal voxel-based morphometry study. ''Front Neurol''. 2025; '''16''': 1579561
Sex similarities and differences in cognition: A longitudinal study of healthy control participants from the Parkinson Progression Markers Initiative.
Description: Ohlhauser, Lisa, et al. Sex similarities and differences in cognition: A longitudinal study of healthy control participants from the Parkinson Progression Markers Initiative. ''PLoS One''. 2025; '''20''' (11):e0334358
Sex-specific brain morphological and network differences in patients showing Parkinson's disease with and without possible rapid eye movement sleep behavior disorder.
Description: Liu, Yang, et al. Sex-specific brain morphological and network differences in patients showing Parkinson's disease with and without possible rapid eye movement sleep behavior disorder. ''Front Neurol''. 2025; '''16''': 1561555
Striatal dopaminergic patterns and clinical features in frontotemporal dementia.
Description: Urso, Daniele, et al. Striatal dopaminergic patterns and clinical features in frontotemporal dementia. ''Brain Commun''. 2025; '''7''' (4):fcaf284
Sweet spot mapping and structural connectivity in subthalamic stimulation: predicting neuropsychiatric outcomes in Parkinson's disease.
Description: Yan, Jiuqi, et al. Sweet spot mapping and structural connectivity in subthalamic stimulation: predicting neuropsychiatric outcomes in Parkinson's disease. ''Front Neurosci''. 2025; '''19''': 1577588
Transcriptomics profiling of Parkinson's disease progression subtypes reveals distinctive patterns of gene expression.
Description: Fabrizio, Carlo, et al. Transcriptomics profiling of Parkinson's disease progression subtypes reveals distinctive patterns of gene expression. ''J Cent Nerv Syst Dis''. 2025; '''17''': 11795735241286821
HeteroMRI: Robust white matter abnormality classification across multi-scanner MRI data.
Description: Abedi, Masoud, et al. HeteroMRI: Robust white matter abnormality classification across multi-scanner MRI data. ''Gigascience''. 2025 Jan 6; '''14''':
Clinically probable RBD is an early predictor of malignant non-motor Parkinson's disease phenotypes.
Description: Martinez-Nunez, Alfonso Enrique, et al. Clinically probable RBD is an early predictor of malignant non-motor Parkinson's disease phenotypes. ''NPJ Parkinsons Dis''. 2025 Jan 29; '''11''' (1):25
Increased plasma DOPA decarboxylase levels in Lewy body disorders are driven by dopaminergic treatment.
Description: Bolsewig, Katharina, et al. Increased plasma DOPA decarboxylase levels in Lewy body disorders are driven by dopaminergic treatment. ''Nat Commun''. 2025 Jan 29; '''16''' (1):1139
Dopaminergic PET to SPECT domain adaptation: a cycle GAN translation approach.
Description: Lopes, Leonor, et al. Dopaminergic PET to SPECT domain adaptation: a cycle GAN translation approach. ''Eur J Nucl Med Mol Imaging''. 2025 Feb; '''52''' (3):851-863
Identification of Depression Subtypes in Parkinson's Disease Patients via Structural MRI Whole-Brain Radiomics: An Unsupervised Machine Learning Study.
Description: Zhang, Zihan, et al. Identification of Depression Subtypes in Parkinson's Disease Patients via Structural MRI Whole-Brain Radiomics: An Unsupervised Machine Learning Study. ''CNS Neurosci Ther''. 2025 Feb; '''31''' (2):e70182
Impact of excessive daytime sleepiness on the progression of freezing of gait in de novo Parkinson's disease: a cohort study.
Description: Chen, Min, et al. Impact of excessive daytime sleepiness on the progression of freezing of gait in de novo Parkinson's disease: a cohort study. ''Neurol Sci''. 2025 Feb; '''46''' (2):723-731
Polygenic scores for disease risk are not associated with clinical outcomes in Parkinson's disease.
Description: Tan, Manuela Mx, et al. Polygenic scores for disease risk are not associated with clinical outcomes in Parkinson's disease. ''medRxiv''. 2025 Feb 3;
Coffee consumption is associated with later age-at-onset of Parkinson's disease.
Description: Kuzovenkova, Dariia, et al. Coffee consumption is associated with later age-at-onset of Parkinson's disease. ''medRxiv''. 2025 Feb 10;
Motor and nonmotor features of p.A53T alpha-synuclein PD vs idiopathic PD: longitudinal data from the PPMI study.
Description: Simitsi, Athina Maria, et al. Motor and nonmotor features of p.A53T alpha-synuclein PD vs idiopathic PD: longitudinal data from the PPMI study. ''J Neurol''. 2025 Feb 12; '''272''' (3):203
Patient-centered brain transcriptomic and multimodal imaging determinants of clinical progression, physical activity, and treatment needs in Parkinson's disease.
Description: Adewale, Quadri, et al. Patient-centered brain transcriptomic and multimodal imaging determinants of clinical progression, physical activity, and treatment needs in Parkinson's disease. ''NPJ Parkinsons Dis''. 2025 Feb 15; '''11''' (1):29
RGS10 attenuates systemic immune dysregulation induced by chronic inflammatory stress.
Description: Jernigan, Janna E, et al. RGS10 attenuates systemic immune dysregulation induced by chronic inflammatory stress. ''J Neuroinflammation''. 2025 Feb 24; '''22''' (1):49
23ME-01473, an Fc Effector-Enhanced Anti-ULBP6/2/5 Antibody, Restores NK Cell-Mediated Antitumor Immunity through NKG2D and FcgammaRIIIa Activation.
Description: Benjamin, Joel S, et al. 23ME-01473, an Fc Effector-Enhanced Anti-ULBP6/2/5 Antibody, Restores NK Cell-Mediated Antitumor Immunity through NKG2D and FcgammaRIIIa Activation. ''Cancer Res Commun''. 2025 Mar 1; '''5''' (3):476-495
History of Traumatic Brain Injury Does Not Influence Rate of Progression of Clinical or Pathological Outcomes in Two Early Parkinson's Disease Cohorts.
Description: McNamara, Angus, et al. History of Traumatic Brain Injury Does Not Influence Rate of Progression of Clinical or Pathological Outcomes in Two Early Parkinson's Disease Cohorts. ''Eur J Neurol''. 2025 Mar; '''32''' (3):e70090
Incorporating label uncertainty during the training of convolutional neural networks improves performance for the discrimination between certain and inconclusive cases in dopamine transporter SPECT.
Description: Kucerenko, Aleksej, et al. Incorporating label uncertainty during the training of convolutional neural networks improves performance for the discrimination between certain and inconclusive cases in dopamine transporter SPECT. ''Eur J Nucl Med Mol Imaging''. 2025 Mar; '''52''' (4):1535-1548
Unsupervised subtyping of motor dysfunction of Parkinson's disease and its structural brain imaging correlates.
Description: Lin, Yu-Fan, et al. Unsupervised subtyping of motor dysfunction of Parkinson's disease and its structural brain imaging correlates. ''Neuroimage Rep''. 2025 Mar; '''5''' (1):100246
Epigenetic insights into neuropsychiatric and cognitive symptoms in Parkinson's disease: A DNA co-methylation network analysis.
Description: Harvey, Joshua, et al. Epigenetic insights into neuropsychiatric and cognitive symptoms in Parkinson's disease: A DNA co-methylation network analysis. ''NPJ Parkinsons Dis''. 2025 Mar 2; '''11''' (1):39
A novel integrative multimodal classifier to enhance the diagnosis of Parkinson's disease.
Description: Zhou, Xiaoyan, et al. A novel integrative multimodal classifier to enhance the diagnosis of Parkinson's disease. ''Brief Bioinform''. 2025 Mar 4; '''26''' (2):
AskBeacon-performing genomic data exchange and analytics with natural language.
Description: Wickramarachchi, Anuradha, et al. AskBeacon-performing genomic data exchange and analytics with natural language. ''Bioinformatics''. 2025 Mar 4; '''41''' (3):
Male sex accelerates cognitive decline in GBA1 Parkinson's disease.
Description: Caminiti, Silvia Paola, et al. Male sex accelerates cognitive decline in GBA1 Parkinson's disease. ''NPJ Parkinsons Dis''. 2025 Mar 4; '''11''' (1):41
Atrophy of ventral diencephalon is associated with freezing of gait in Parkinson's disease: analysis of two cohorts.
Description: Wang, Xuemei, et al. Atrophy of ventral diencephalon is associated with freezing of gait in Parkinson's disease: analysis of two cohorts. ''NPJ Parkinsons Dis''. 2025 Mar 6; '''11''' (1):44
Predicting Cerebrospinal Fluid Alpha-Synuclein Seed Amplification Assay Status from Demographics and Clinical Data.
Description: Venuto, Charles S, et al. Predicting Cerebrospinal Fluid Alpha-Synuclein Seed Amplification Assay Status from Demographics and Clinical Data. ''medRxiv''. 2025 Mar 7;
alpha-Synuclein Seed Amplification Assay Amplification Parameters and the Risk of Progression in Prodromal Parkinson Disease.
Description: Coughlin, David G, et al. alpha-Synuclein Seed Amplification Assay Amplification Parameters and the Risk of Progression in Prodromal Parkinson Disease. ''Neurology''. 2025 Mar 11; '''104''' (5):e210279
A Narrative Review on Biochemical Markers and Emerging Treatments in Prodromal Synucleinopathies.
Description: Rissardo, Jamir Pitton, et al. A Narrative Review on Biochemical Markers and Emerging Treatments in Prodromal Synucleinopathies. ''Clin Pract''. 2025 Mar 17; '''15''' (3):
Haploinsufficiency of ITSN1 is associated with a substantial increased risk of Parkinson's disease.
Description: Spargo, Thomas P, et al. Haploinsufficiency of ITSN1 is associated with a substantial increased risk of Parkinson's disease. ''Cell Rep''. 2025 Mar 25; '''44''' (3):115355
Decline in striatal binding ratio associated with accelerated decline in performance on symbol digit modality but not MoCA in Parkinson's Disease Psychosis.
Description: Pisani, Sara, et al. Decline in striatal binding ratio associated with accelerated decline in performance on symbol digit modality but not MoCA in Parkinson's Disease Psychosis. ''BMJ Ment Health''. 2025 Mar 31; '''28''' (1):
A Multi-omics Framework Based on Machine Learning as a Predictor of Cognitive Impairment Progression in Early Parkinson's Disease.
Description: Luo, Yang, et al. A Multi-omics Framework Based on Machine Learning as a Predictor of Cognitive Impairment Progression in Early Parkinson's Disease. ''Neurol Ther''. 2025 Apr; '''14''' (2):643-658
Epigenome-wide association study, meta-analysis, and multiscore profiling of whole blood in Parkinson's disease.
Description: Lie, Ingeborg Haugesag, et al. Epigenome-wide association study, meta-analysis, and multiscore profiling of whole blood in Parkinson's disease. ''Ann Clin Transl Neurol''. 2025 Apr; '''12''' (4):701-713
Neuropsychiatric symptoms and neuroimaging-based brain age in mild cognitive impairment and early dementia: A multicenter study.
Description: Sone, Daichi, et al. Neuropsychiatric symptoms and neuroimaging-based brain age in mild cognitive impairment and early dementia: A multicenter study. ''Psychiatry Clin Neurosci''. 2025 Apr; '''79''' (4):158-164
Staged Screening Identifies People with Biomarkers Related to Neuronal Alpha-Synuclein Disease.
Description: Brown, Ethan G, et al. Staged Screening Identifies People with Biomarkers Related to Neuronal Alpha-Synuclein Disease. ''Ann Neurol''. 2025 Apr; '''97''' (4):730-740
Predictive modeling to uncover Parkinson's disease characteristics that delay diagnosis.
Description: Hahnel, Tom, et al. Predictive modeling to uncover Parkinson's disease characteristics that delay diagnosis. ''NPJ Parkinsons Dis''. 2025 Apr 2; '''11''' (1):64
Hyposmia in Parkinson's disease; exploring selective odour loss.
Description: Mitchell, Eleanor, et al. Hyposmia in Parkinson's disease; exploring selective odour loss. ''NPJ Parkinsons Dis''. 2025 Apr 4; '''11''' (1):67
Independent validation of the PrecivityAD2() blood test to identify presence or absence of brain amyloid pathology in individuals with cognitive impairment.
Description: Coppinger, Justine, et al. Independent validation of the PrecivityAD2() blood test to identify presence or absence of brain amyloid pathology in individuals with cognitive impairment. ''medRxiv''. 2025 Apr 7;
Assessing DNA methylation detection for primary human tissue using Nanopore sequencing.
Description: Genner, Rylee, et al. Assessing DNA methylation detection for primary human tissue using Nanopore sequencing. ''Genome Res''. 2025 Apr 14; '''35''' (4):632-643
Shared pathway-specific network mechanisms of dopamine and deep brain stimulation for the treatment of Parkinson's disease.
Description: Binns, Thomas S, et al. Shared pathway-specific network mechanisms of dopamine and deep brain stimulation for the treatment of Parkinson's disease. ''Nat Commun''. 2025 Apr 15; '''16''' (1):3587
Four questions to predict cognitive decline in de novo Parkinson's disease.
Description: Hlavnicka, Jan, et al. Four questions to predict cognitive decline in de novo Parkinson's disease. ''NPJ Parkinsons Dis''. 2025 Apr 25; '''11''' (1):91
Harnessing routine MRI for the early screening of Parkinson's disease: a multicenter machine learning study using T2-weighted FLAIR imaging.
Description: Fu, Junyan, et al. Harnessing routine MRI for the early screening of Parkinson's disease: a multicenter machine learning study using T2-weighted FLAIR imaging. ''Insights Imaging''. 2025 Apr 26; '''16''' (1):92
Early BMI Change, Cognitive Decline, and CSF AD Biomarkers Alterations in Parkinson's Disease.
Description: Zhong, Rui, et al. Early BMI Change, Cognitive Decline, and CSF AD Biomarkers Alterations in Parkinson's Disease. ''Ann Clin Transl Neurol''. 2025 May; '''12''' (5):898-904
Examining the Relationship Between Physical Function and Anxiety/Depression in Parkinson's.
Description: Hodgson, Philip, et al. Examining the Relationship Between Physical Function and Anxiety/Depression in Parkinson's. ''Brain Behav''. 2025 May; '''15''' (5):e70563
Item Response Modeling and Artificial Neural Network for Differentiation of Parkinson's Patients and Subjects Without Evidence of Dopaminergic Deficit.
Description: Arrington, Leticia, et al. Item Response Modeling and Artificial Neural Network for Differentiation of Parkinson's Patients and Subjects Without Evidence of Dopaminergic Deficit. ''CPT Pharmacometrics Syst Pharmacol''. 2025 May; '''14''' (5):881-890
Plasma Glucosylceramide Levels Are Regulated by ATP10D and Are Not Involved in Parkinson's Disease Pathogenesis.
Description: Somerville, Emma N, et al. Plasma Glucosylceramide Levels Are Regulated by ATP10D and Are Not Involved in Parkinson's Disease Pathogenesis. ''Ann Neurol''. 2025 May; '''97''' (5):873-878
Pre-symptomatic Parkinson's disease blood test quantifying repetitive sequence motifs in transfer RNA fragments.
Description: Madrer, Nimrod, et al. Pre-symptomatic Parkinson's disease blood test quantifying repetitive sequence motifs in transfer RNA fragments. ''Nat Aging''. 2025 May; '''5''' (5):868-882
Relationships between neuropsychiatric symptoms, subtypes of astrocyte activities, and brain pathologies in Alzheimer's disease and Parkinson's disease.
Description: Li, Oceanna Yueran, et al. Relationships between neuropsychiatric symptoms, subtypes of astrocyte activities, and brain pathologies in Alzheimer's disease and Parkinson's disease. ''Alzheimers Dement''. 2025 May; '''21''' (5):e70242
Probabilistic Mapping and Automated Segmentation of Human Brainstem White Matter Bundles.
Description: Olchanyi, Mark D, et al. Probabilistic Mapping and Automated Segmentation of Human Brainstem White Matter Bundles. ''medRxiv''. 2025 May 5;
Modulatory effect of levodopa on the basal ganglia-cerebellum connectivity in Parkinson's disease.
Description: Yun, Juyoung Jenna, et al. Modulatory effect of levodopa on the basal ganglia-cerebellum connectivity in Parkinson's disease. ''NPJ Parkinsons Dis''. 2025 May 6; '''11''' (1):115
Data-driven characterization of distinct cognitive subtypes in Parkinson's disease dementia.
Description: Labrador-Espinosa, Miguel A, et al. Data-driven characterization of distinct cognitive subtypes in Parkinson's disease dementia. ''NPJ Parkinsons Dis''. 2025 May 9; '''11''' (1):119
Cortical connectivity predicts cognition across time in Parkinson's disease.
Description: Twedt, Hunter P, et al. Cortical connectivity predicts cognition across time in Parkinson's disease. ''medRxiv''. 2025 May 13;
Predicting dementia in people with Parkinson's disease.
Description: Aborageh, Mohamed, et al. Predicting dementia in people with Parkinson's disease. ''NPJ Parkinsons Dis''. 2025 May 13; '''11''' (1):126
T cell responses towards PINK1 and alpha-synuclein are elevated in prodromal Parkinson's disease.
Description: Johansson, Emil, et al. T cell responses towards PINK1 and alpha-synuclein are elevated in prodromal Parkinson's disease. ''NPJ Parkinsons Dis''. 2025 May 26; '''11''' (1):137
Increased burden of rare risk variants across gene expression networks predisposes to sporadic Parkinson's disease.
Description: Eubanks, Elena, et al. Increased burden of rare risk variants across gene expression networks predisposes to sporadic Parkinson's disease. ''Cell Rep''. 2025 May 27; '''44''' (5):115636
Clinical and Functional Connectivity Markers in Prediction of Hallucinations in Parkinson's Disease.
Description: Li, Guanglu, et al. Clinical and Functional Connectivity Markers in Prediction of Hallucinations in Parkinson's Disease. ''CNS Neurosci Ther''. 2025 Jun; '''31''' (6):e70432
Regional Brain Aging Disparity Index: Region-Specific Brain Aging State Index for Neurodegenerative Diseases and Chronic Disease Specificity.
Description: Wu, Yutong, et al. Regional Brain Aging Disparity Index: Region-Specific Brain Aging State Index for Neurodegenerative Diseases and Chronic Disease Specificity. ''Bioengineering (Basel)''. 2025 Jun 3; '''12''' (6):
Optimizing wrist-worn wearable compliance with insights from two Parkinson's disease cohort studies.
Description: Meinders, Marjan J, et al. Optimizing wrist-worn wearable compliance with insights from two Parkinson's disease cohort studies. ''NPJ Parkinsons Dis''. 2025 Jun 6; '''11''' (1):152
Peripheral inflammation's variable impact on cognitive and symptomatic outcomes in Parkinson's disease: a longitudinal and cross-sectional analysis.
Description: He, Peikun, et al. Peripheral inflammation's variable impact on cognitive and symptomatic outcomes in Parkinson's disease: a longitudinal and cross-sectional analysis. ''NPJ Parkinsons Dis''. 2025 Jun 7; '''11''' (1):155
Coffee Consumption Is Associated With Later Age-at-Onset of Parkinson's Disease.
Description: Kuzovenkova, Dariia, et al. Coffee Consumption Is Associated With Later Age-at-Onset of Parkinson's Disease. ''Ann Clin Transl Neurol''. 2025 Jun 12; '''12''' (8):1706-10
Longitudinal assessment of the association between pesticide exposure and lifestyle with Parkinson's disease motor severity.
Description: Luth, Theresa, et al. Longitudinal assessment of the association between pesticide exposure and lifestyle with Parkinson's disease motor severity. ''NPJ Parkinsons Dis''. 2025 Jun 12; '''11''' (1):164
Wrist accelerometry and machine learning sensitively capture disease progression in prodromal Parkinson's disease.
Description: Gupta, Anoopum S, et al. Wrist accelerometry and machine learning sensitively capture disease progression in prodromal Parkinson's disease. ''NPJ Parkinsons Dis''. 2025 Jun 17; '''11''' (1):171
A Comprehensive Study of Circulating Blood Linear RNA nominates CD55 and DLD as novel causal genes and early-stage biomarkers for Parkinson's Disease.
Description: Beric, Aleksandra, et al. A Comprehensive Study of Circulating Blood Linear RNA nominates CD55 and DLD as novel causal genes and early-stage biomarkers for Parkinson's Disease. ''medRxiv''. 2025 Jun 20;
Clinical progression and genetic pathways in body-first and brain-first Parkinson's disease.
Description: Passaretti, Massimiliano, et al. Clinical progression and genetic pathways in body-first and brain-first Parkinson's disease. ''Mol Neurodegener''. 2025 Jun 20; '''20''' (1):74
Dopamine and cortical neurons with different Parkinsonian mutations show variation in lysosomal and mitochondrial dysfunction.
Description: Chedid, Jessica, et al. Dopamine and cortical neurons with different Parkinsonian mutations show variation in lysosomal and mitochondrial dysfunction. ''NPJ Parkinsons Dis''. 2025 Jun 20; '''11''' (1):177
Evaluating language model embeddings for Parkinson's disease cohort harmonization using a novel manually curated variable mapping schema.
Description: Salimi, Yasamin, et al. Evaluating language model embeddings for Parkinson's disease cohort harmonization using a novel manually curated variable mapping schema. ''Sci Rep''. 2025 Jun 20; '''15''' (1):20210
Comparative Analysis of Progression Milestones Across Parkinson's Disease Clinical, Pathological, and Data-driven Subtypes: A 10-year follow-up.
Description: Negida, Ahmed, et al. Comparative Analysis of Progression Milestones Across Parkinson's Disease Clinical, Pathological, and Data-driven Subtypes: A 10-year follow-up. ''Res Sq''. 2025 Jun 23;
Distinct brain atrophy progression subtypes underlie phenoconversion in isolated REM sleep behaviour disorder.
Description: Joza, Stephen, et al. Distinct brain atrophy progression subtypes underlie phenoconversion in isolated REM sleep behaviour disorder. ''EBioMedicine''. 2025 Jul; '''117''': 105753
Dopamine Transporter Imaging as Objective Monitoring Biomarker in Parkinson's Disease.
Description: Dzialas, Verena, et al. Dopamine Transporter Imaging as Objective Monitoring Biomarker in Parkinson's Disease. ''Ann Neurol''. 2025 Jul; '''98''' (1):120-135
Neuronal alpha-Synuclein Disease Stage Progression over 5 Years.
Description: Simuni, Tanya, et al. Neuronal alpha-Synuclein Disease Stage Progression over 5 Years. ''Mov Disord''. 2025 Jul; '''40''' (7):1318-1330
The Parkinson's Disease Cognitive Composite: Lessons Forgotten from Preclinical Alzheimer's Cognitive Composites.
Description: Gonzalez, David Andres, et al. The Parkinson's Disease Cognitive Composite: Lessons Forgotten from Preclinical Alzheimer's Cognitive Composites. ''Mov Disord''. 2025 Jul; '''40''' (7):1442-1443
Trajectories of Pontine Volume in Patients with Multiple System Atrophy.
Description: Kawabata, Kazuya, et al. Trajectories of Pontine Volume in Patients with Multiple System Atrophy. ''Mov Disord''. 2025 Jul; '''40''' (7):1369-1378
Wearables-derived risk score for unintrusive detection of alpha-synuclein aggregation or dopaminergic deficit.
Description: Schalkamp, Ann-Kathrin, et al. Wearables-derived risk score for unintrusive detection of alpha-synuclein aggregation or dopaminergic deficit. ''EBioMedicine''. 2025 Jul; '''117''': 105782
Human pegivirus alters brain and blood immune and transcriptomic profiles of patients with Parkinson's disease.
Description: Hanson, Barbara A, et al. Human pegivirus alters brain and blood immune and transcriptomic profiles of patients with Parkinson's disease. ''JCI Insight''. 2025 Jul 8; '''10''' (13):
Protein-based Diagnosis and Analysis of Co-pathologies Across Neurodegenerative Diseases: Large-Scale AI-Boosted CSF and Plasma Classification.
Description: Xu, Ying, et al. Protein-based Diagnosis and Analysis of Co-pathologies Across Neurodegenerative Diseases: Large-Scale AI-Boosted CSF and Plasma Classification. ''medRxiv''. 2025 Jul 10;
Charting structural brain asymmetry across the human lifespan.
Description: Dorfschmidt, Lena, et al. Charting structural brain asymmetry across the human lifespan. ''bioRxiv''. 2025 Jul 24;
Altered network efficiency in isolated REM sleep behavior disorder: A multicentric study.
Description: Tremblay, Christina, et al. Altered network efficiency in isolated REM sleep behavior disorder: A multicentric study. ''Alzheimers Dement''. 2025 Aug; '''21''' (8):e70574
CSF Biomarker-Based Cognitive Trajectories in Parkinson's Disease-Subjective Cognitive Decline.
Description: Rodriguez-Antiguedad, Jon, et al. CSF Biomarker-Based Cognitive Trajectories in Parkinson's Disease-Subjective Cognitive Decline. ''Ann Clin Transl Neurol''. 2025 Aug; '''12''' (8):1575-1584
Development and Validation of PARCOMS Composite Scales for Assessing Disease Progression and Treatment Effects in Parkinson's Disease.
Description: L'Italien, Gil, et al. Development and Validation of PARCOMS Composite Scales for Assessing Disease Progression and Treatment Effects in Parkinson's Disease. ''Neurol Ther''. 2025 Aug; '''14''' (4):1609-1625
Distinct Longitudinal Clinical-Neuroanatomical Trajectories in Parkinson's Disease Clinical Subtypes: Insight toward Precision Medicine.
Description: Fereshtehnejad, Seyed-Mohammad, et al. Distinct Longitudinal Clinical-Neuroanatomical Trajectories in Parkinson's Disease Clinical Subtypes: Insight toward Precision Medicine. ''Mov Disord''. 2025 Aug; '''40''' (8):1572-1583
Exploring the relationship between dystonia and STN-DBS in Parkinson's disease: insights from a single-centre cohort.
Description: Remore, Luigi G, et al. Exploring the relationship between dystonia and STN-DBS in Parkinson's disease: insights from a single-centre cohort. ''Neurol Sci''. 2025 Aug; '''46''' (8):3691-3701
Interpretable Machine Learning for Cross-Cohort Prediction of Motor Fluctuations in Parkinson's Disease.
Description: Loo, Rebecca Ting Jiin, et al. Interpretable Machine Learning for Cross-Cohort Prediction of Motor Fluctuations in Parkinson's Disease. ''Mov Disord''. 2025 Aug; '''40''' (8):1604-1617
Two-step detection of Lewy body pathology via smell-function testing and CSF alpha-synuclein seed amplification.
Description: Mastenbroek, Sophie E, et al. Two-step detection of Lewy body pathology via smell-function testing and CSF alpha-synuclein seed amplification. ''Nat Commun''. 2025 Aug 5; '''16''' (1):7182
LRRK2 kinase activity regulates Parkinson's disease-relevant lipids at the lysosome.
Description: Maloney, Michael T, et al. LRRK2 kinase activity regulates Parkinson's disease-relevant lipids at the lysosome. ''Mol Neurodegener''. 2025 Aug 6; '''20''' (1):89
Triglyceride-glucose index predicts cognitive decline and striatal dopamine deficiency in Parkinson disease in two cohorts.
Description: Cao, Huimin, et al. Triglyceride-glucose index predicts cognitive decline and striatal dopamine deficiency in Parkinson disease in two cohorts. ''NPJ Parkinsons Dis''. 2025 Aug 13; '''11''' (1):240
Biobank-scale genetic characterization of Alzheimer's disease and related dementias across diverse ancestries.
Description: Khani, Marzieh, et al. Biobank-scale genetic characterization of Alzheimer's disease and related dementias across diverse ancestries. ''Nat Commun''. 2025 Aug 14; '''16''' (1):7554
Faster reaction times of CSF Alpha-Synuclein Seed Amplification Assay predict the Diffuse Malignant subtype of Parkinson's Disease at 10-year follow-up.
Description: Grillo, Piergiorgio, et al. Faster reaction times of CSF Alpha-Synuclein Seed Amplification Assay predict the Diffuse Malignant subtype of Parkinson's Disease at 10-year follow-up. ''medRxiv''. 2025 Aug 25;
Longitudinal non-negative matrix factorization identifies the altered trajectory of motor symptoms in Parkinson's disease.
Description: Hou, Xinmin, et al. Longitudinal non-negative matrix factorization identifies the altered trajectory of motor symptoms in Parkinson's disease. ''NPJ Parkinsons Dis''. 2025 Aug 28; '''11''' (1):263
A blood-based DNA damage signature in patients with Parkinson's disease is associated with disease progression.
Description: Sproviero, Daisy, et al. A blood-based DNA damage signature in patients with Parkinson's disease is associated with disease progression. ''Nat Aging''. 2025 Sep; '''5''' (9):1844-1861
Baseline alpha-synuclein seeding activity and disease progression in sporadic and genetic Parkinson's disease in the PPMI cohort.
Description: Schumacher, Jackson G, et al. Baseline alpha-synuclein seeding activity and disease progression in sporadic and genetic Parkinson's disease in the PPMI cohort. ''EBioMedicine''. 2025 Sep; '''119''': 105866
Cognitive Performance in Early Neuronal Synuclein Disease with Hyposmia but without Motor Disability: Association with Dopamine Deficiency and Isolated Rapid Eye Movement Sleep Behavior Disorder.
Description: Weintraub, Daniel, et al. Cognitive Performance in Early Neuronal Synuclein Disease with Hyposmia but without Motor Disability: Association with Dopamine Deficiency and Isolated Rapid Eye Movement Sleep Behavior Disorder. ''Ann Neurol''. 2025 Sep; '''98''' (3):482-491
Dopamine genetic risk scores and psychiatric symptoms: Interacting risk factors for impulse control behaviours in de novo Parkinson's disease.
Description: Whooley, Emma, et al. Dopamine genetic risk scores and psychiatric symptoms: Interacting risk factors for impulse control behaviours in de novo Parkinson's disease. ''J Neuropsychol''. 2025 Sep; '''19''' (3):443-453
Free water predicts dementia with Lewy bodies in isolated REM sleep behavior disorder.
Description: Haddad, Celine, et al. Free water predicts dementia with Lewy bodies in isolated REM sleep behavior disorder. ''Alzheimers Dement''. 2025 Sep; '''21''' (9):e70570
Genome-Wide Association Study of Glucocerebrosidase Activity Modifiers.
Description: Somerville, Emma N, et al. Genome-Wide Association Study of Glucocerebrosidase Activity Modifiers. ''Mol Neurobiol''. 2025 Sep; '''62''' (9):11560-11571
Lifespan Tree of Brain Anatomy: Diagnostic Values for Motor and Cognitive Neurodegenerative Diseases.
Description: Coupe, Pierrick, et al. Lifespan Tree of Brain Anatomy: Diagnostic Values for Motor and Cognitive Neurodegenerative Diseases. ''Hum Brain Mapp''. 2025 Sep; '''46''' (13):e70336
The Effect of Genotype on Self-Reported Dysarthria and Dysphagia in Parkinson's Disease: A Parkinson's Progression Marker Initiative Study.
Description: Dumican, Matthew, et al. The Effect of Genotype on Self-Reported Dysarthria and Dysphagia in Parkinson's Disease: A Parkinson's Progression Marker Initiative Study. ''Int J Lang Commun Disord''. 2025 Sep-Oct; '''60''' (5):e70124
A Common PD-Risk GBA1 Variant Disrupts LIMP2 Interaction, Impairs Glucocerebrosidase Function, and Drives Lysosomal and Mitochondrial Dysfunction.
Description: Davis, Oliver B, et al. A Common PD-Risk GBA1 Variant Disrupts LIMP2 Interaction, Impairs Glucocerebrosidase Function, and Drives Lysosomal and Mitochondrial Dysfunction. ''bioRxiv''. 2025 Sep 2;
No Evidence for Genetic Role of the Tumor Necrosis Factor Pathway in Parkinson's Disease.
Description: Shahkhali, Morvarid Ghamgosar, et al. No Evidence for Genetic Role of the Tumor Necrosis Factor Pathway in Parkinson's Disease. ''medRxiv''. 2025 Sep 8;
Differential modulation of movement speed with state-dependent deep brain stimulation in Parkinson's disease.
Description: Cavallo, Alessia, et al. Differential modulation of movement speed with state-dependent deep brain stimulation in Parkinson's disease. ''Sci Adv''. 2025 Sep 12; '''11''' (37):eadx6849
Fall Frequency, Risk Factors, and Outcomes in Parkinson's Disease: A Cross-Sectional Analysis.
Description: Vizcarra, Joaquin A, et al. Fall Frequency, Risk Factors, and Outcomes in Parkinson's Disease: A Cross-Sectional Analysis. ''medRxiv''. 2025 Sep 25;
Cross-regional radiomics: a novel framework for relationship-based feature extraction with validation in Parkinson's disease motor subtyping.
Description: Hosseini, Mahboube Sadat, et al. Cross-regional radiomics: a novel framework for relationship-based feature extraction with validation in Parkinson's disease motor subtyping. ''BioData Min''. 2025 Sep 29; '''18''' (1):67
Independent Associations of Sleep and Walking with Cognition in Parkinson's Disease: A Perivascular Spaces Analysis.
Description: Sibilia, Francesca, et al. Independent Associations of Sleep and Walking with Cognition in Parkinson's Disease: A Perivascular Spaces Analysis. ''bioRxiv''. 2025 Sep 29;
Thalamic nuclei volume changes associated with cognitive and motor manifestations of Parkinson's disease.
Description: Ferrer-Gallardo, Vicente J, et al. Thalamic nuclei volume changes associated with cognitive and motor manifestations of Parkinson's disease. ''NPJ Parkinsons Dis''. 2025 Sep 30; '''11''' (1):279
Glymphatic Function in Prodromal Parkinson's Disease: Associations With Symptoms, Gray Matter Volume, and Phenoconversion Risk.
Description: Chen, Amei, et al. Glymphatic Function in Prodromal Parkinson's Disease: Associations With Symptoms, Gray Matter Volume, and Phenoconversion Risk. ''Eur J Neurol''. 2025 Oct; '''32''' (10):e70389
Percentile scores for the revised University of Pennsylvania Smell Identification Test for 16,972 individuals 60 years of age and older.
Description: Pierz, Kerri A, et al. Percentile scores for the revised University of Pennsylvania Smell Identification Test for 16,972 individuals 60 years of age and older. ''NPJ Parkinsons Dis''. 2025 Oct 1; '''11''' (1):280
Protective Effects of Genetic Proxies of Cognitive Reserve in Parkinson's Disease: A Longitudinal Multi-Cohort Study.
Description: Huh, Young Eun, et al. Protective Effects of Genetic Proxies of Cognitive Reserve in Parkinson's Disease: A Longitudinal Multi-Cohort Study. ''Mov Disord''. 2025 Oct; '''40''' (10):2158-2168
HMGCR genetic variability in Parkinson's disease in a Spanish cohort: associations with lipid metabolism and early onset.
Description: Diaz-Belloso, Rafael, et al. HMGCR genetic variability in Parkinson's disease in a Spanish cohort: associations with lipid metabolism and early onset. ''J Neurol''. 2025 Oct 2; '''272''' (10):671
Estimation of reference curves for brain atrophy and analysis of robustness to machine effects.
Description: Piot, Elodie, et al. Estimation of reference curves for brain atrophy and analysis of robustness to machine effects. ''Sci Rep''. 2025 Oct 3; '''15''' (1):34585
Lifespan Normative Modeling of Brain Microstructure.
Description: Villalon-Reina, Julio E, et al. Lifespan Normative Modeling of Brain Microstructure. ''bioRxiv''. 2025 Oct 4;
Association of DTI-ALPS Glymphatic Index With Differential Phenoconversion in Isolated REM Sleep Behavior Disorder: A Multi-Cohort MRI Study.
Description: Ayral, Violette, et al. Association of DTI-ALPS Glymphatic Index With Differential Phenoconversion in Isolated REM Sleep Behavior Disorder: A Multi-Cohort MRI Study. ''Neurology''. 2025 Oct 7; '''105''' (7):e214042
The effects of aquaporin-4 polymorphisms on glymphatic function and motor symptoms in Parkinson's disease.
Description: Qin, Jianmei, et al. The effects of aquaporin-4 polymorphisms on glymphatic function and motor symptoms in Parkinson's disease. ''NPJ Parkinsons Dis''. 2025 Oct 8; '''11''' (1):288
Estrogen-related receptor gene expression associates with sex differences in cortical atrophy in isolated REM sleep behavior disorder.
Description: Filiatrault, Marie, et al. Estrogen-related receptor gene expression associates with sex differences in cortical atrophy in isolated REM sleep behavior disorder. ''Nat Commun''. 2025 Oct 10; '''16''' (1):9016
Decreased SNCA expression in whole-blood RNA analysis of Parkinson's disease adjusting for neutrophils.
Description: Xu, Kayla Y, et al. Decreased SNCA expression in whole-blood RNA analysis of Parkinson's disease adjusting for neutrophils. ''NPJ Parkinsons Dis''. 2025 Oct 14; '''11''' (1):292
Optimizing the MDS-UPDRS Part III for early-stage Parkinson's: early supportive evidence for a limb-related bradykinesia/rigidity sub-score.
Description: Regnault, Antoine, et al. Optimizing the MDS-UPDRS Part III for early-stage Parkinson's: early supportive evidence for a limb-related bradykinesia/rigidity sub-score. ''NPJ Parkinsons Dis''. 2025 Oct 17; '''11''' (1):297
Neural networks reveal novel gene signatures in Parkinson disease from single-nuclei transcriptomes.
Description: Fiorini, Michael R, et al. Neural networks reveal novel gene signatures in Parkinson disease from single-nuclei transcriptomes. ''NPJ Parkinsons Dis''. 2025 Oct 21; '''11''' (1):304
Brain age gap as a predictive biomarker that links aging, lifestyle, and neuropsychiatric health.
Description: Zhang, Ruixia, et al. Brain age gap as a predictive biomarker that links aging, lifestyle, and neuropsychiatric health. ''Commun Med (Lond)''. 2025 Oct 24; '''5''' (1):441
Explore brain-inspired machine intelligence for connecting dots on graphs through holographic blueprint of oscillatory synchronization.
Description: Dan, Tingting, et al. Explore brain-inspired machine intelligence for connecting dots on graphs through holographic blueprint of oscillatory synchronization. ''Nat Commun''. 2025 Oct 24; '''16''' (1):9425
Synergistic blood-based diagnostic value of AP3B1 and BMPR2 in Parkinson's disease.
Description: Zhao, Xiyan, et al. Synergistic blood-based diagnostic value of AP3B1 and BMPR2 in Parkinson's disease. ''NPJ Parkinsons Dis''. 2025 Oct 28; '''11''' (1):310
A Multimodal Deep Learning Approach for White Matter Shape Prediction in Diffusion MRI Tractography.
Description: Lo, Yui, et al. A Multimodal Deep Learning Approach for White Matter Shape Prediction in Diffusion MRI Tractography. ''Hum Brain Mapp''. 2025 Nov; '''46''' (16):e70396
Structural Alterations in the Gray Matter Volume in Rapid-Onset Dystonia-Parkinsonism.
Description: Haq, Ihtsham U, et al. Structural Alterations in the Gray Matter Volume in Rapid-Onset Dystonia-Parkinsonism. ''Mov Disord''. 2025 Nov; '''40''' (11):2510-2516
Volumetric spline-based Kolmogorov-Arnold architectures surpass CNNs, vision transformers, and graph networks for Parkinson's disease detection.
Description: Patel, Salil B, et al. Volumetric spline-based Kolmogorov-Arnold architectures surpass CNNs, vision transformers, and graph networks for Parkinson's disease detection. ''Commun Med (Lond)''. 2025 Nov 3; '''5''' (1):451
Impact of image preprocessing methods on MRI radiomics feature variability and classification performance in Parkinson's disease motor subtype analysis.
Description: Panahi, Mehdi, et al. Impact of image preprocessing methods on MRI radiomics feature variability and classification performance in Parkinson's disease motor subtype analysis. ''Sci Rep''. 2025 Nov 14; '''15''' (1):40030
Predicting mild cognitive impairment in patients with Parkinson's disease by integrating striatal MRI radiomics with clinical features.
Description: Chen, Haisong, et al. Predicting mild cognitive impairment in patients with Parkinson's disease by integrating striatal MRI radiomics with clinical features. ''BMC Med Imaging''. 2025 Nov 14; '''25''' (1):465
Identification of expanded and interrupted ATXN2 repeat expansions in Parkinson's disease and Lewy Body Dementia cohorts.
Description: Wang, Longfei, et al. Identification of expanded and interrupted ATXN2 repeat expansions in Parkinson's disease and Lewy Body Dementia cohorts. ''NPJ Parkinsons Dis''. 2025 Nov 27; '''11''' (1):341
Longitudinal assessment of DNA repair signature trajectory in prodromal versus established Parkinson's disease.
Description: Anwer, Danish, et al. Longitudinal assessment of DNA repair signature trajectory in prodromal versus established Parkinson's disease. ''NPJ Parkinsons Dis''. 2025 Dec 5; '''11''' (1):349